Sema7a - sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A Gene

Mus musculus

Also known as Semal; CDw108; sema L; sema K1; H-Sema-L; M-Sema-L; H-Sema K1; 2900057C09Rik

Gene ID: 20361 | Gene type: protein coding

About Sema7a

Summary

Enables Integrin binding activity. Involved in several processes, including integrin-mediated signaling pathway; positive regulation of ERK1 and ERK2 cascade; and positive regulation of macrophage cytokine production. Acts upstream of or within nervous system development and positive regulation of protein phosphorylation. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Orthologous to human SEMA7A (semaphorin 7A (John Milton Hagen blood group)). [provided by Alliance of Genome Resources, Apr 2022]

Sema7a Products(1)

mRNA	Protein	Name
NM_011352.3	NP_035482.1	semaphorin-7A precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables integrin binding	IPI IPI: Inferred from physical interaction	17377534	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within axon extension	IDA IDA: Inferred from direct assay	12879062	MGI
acts upstream of or within axon extension	IGI IGI: Inferred from genetic interaction	12879062	MGI
acts upstream of or within axon extension	IMP IMP: Inferred from mutant phenotype	12879062	MGI
involved in integrin-mediated signaling pathway	IDA IDA: Inferred from direct assay	17377534	MGI
acts upstream of or within neuron projection development	IMP IMP: Inferred from mutant phenotype	12879062	MGI
acts upstream of or within olfactory lobe development	IDA IDA: Inferred from direct assay	12879062	MGI
acts upstream of or within olfactory lobe development	IMP IMP: Inferred from mutant phenotype	12879062	MGI
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	17377534	MGI
acts upstream of or within positive regulation of axon extension	IDA IDA: Inferred from direct assay	12879062	MGI
involved in positive regulation of macrophage cytokine production	IDA IDA: Inferred from direct assay	17377534	MGI
acts upstream of or within positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	12879062	MGI
acts upstream of protein phosphorylation	IDA IDA: Inferred from direct assay	12879062	MGI
involved in regulation of inflammatory response	IDA IDA: Inferred from direct assay	17377534	MGI
involved in regulation of synapse maturation	IDA IDA: Inferred from direct assay	25201975	MGI
involved in regulation of synapse maturation	IMP IMP: Inferred from mutant phenotype	25201975	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	25201975	MGI
is active in GABA-ergic synapse	IMP IMP: Inferred from mutant phenotype	25201975	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	17377534	MGI
is active in presynapse	IDA IDA: Inferred from direct assay	25201975	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

semaphorin-7A

semaphorin-K1

semaphorin-L

Recombinant Sema7a Proteins

Cat. No.	Product Name	Accession	Purity
HY-P78035	Semaphorin-7A/SEMA7A Protein, Mouse (HEK293, His)	Q9QUR8 (Q45-A646)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12668	SEMA7A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sema7a	NCBI	NCBI:8482

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