Slc2a1 - solute carrier family 2 (facilitated glucose transporter), member 1 Gene

Mus musculus

Also known as Glut1; Glut-1; M100200; Rgsc200

Gene ID: 20525 | Gene type: protein coding

About Slc2a1

Chromosome 4: 118,965,908-118,995,180 forward strand.GRCm39:CM000997.3

This gene has 5 transcripts (splice variants), 374 orthologues, 11 paralogues and is associated with 12 phenotypes. Broad expression in liver E14.5 (RPKM 161.1), placenta adult (RPKM 14.1) and 25 other tissues.

Summary

Enables D-glucose transmembrane transporter activity and dehydroascorbic acid transmembrane transporter activity. Involved in dehydroascorbic acid transport and glucose transmembrane transport. Acts upstream of or within cellular response to glucose starvation. Located in several cellular components, including basolateral plasma membrane; female pronucleus; and photoreceptor inner segment. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in brain disease (multiple); carbohydrate metabolic disorder; myelomeningocele; obesity; and type 2 diabetes mellitus. Orthologous to human SLC2A1 (solute carrier family 2 member 1). [provided by Alliance of Genome Resources, Apr 2022]

Slc2a1 Products(1)

mRNA	Protein	Name
NM_011400.3	NP_035530.2	solute carrier family 2, facilitated glucose transporter member 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables D-glucose transmembrane transporter activity	IDA IDA: Inferred from direct assay	18668520	MGI
enables dehydroascorbic acid transmembrane transporter activity	IDA IDA: Inferred from direct assay	18668520	MGI
enables fucose transmembrane transporter activity	IDA IDA: Inferred from direct assay	36423686	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15975910	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in D-glucose transmembrane transport	IDA IDA: Inferred from direct assay	18668520	MGI
acts upstream of or within cellular response to glucose starvation	IDA IDA: Inferred from direct assay	11259273	MGI
involved in dehydroascorbic acid transport	IDA IDA: Inferred from direct assay	18668520	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Golgi membrane	IDA IDA: Inferred from direct assay	10759149	MGI
located in apical plasma membrane	IDA IDA: Inferred from direct assay	19841136	MGI
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	11259273	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	18668520	MGI
located in cytosol	IDA IDA: Inferred from direct assay	18511518	MGI
located in female germ cell nucleus	IDA IDA: Inferred from direct assay	11259273	MGI
located in female pronucleus	IDA IDA: Inferred from direct assay	11259273	MGI
located in intracellular anatomical structure	IDA IDA: Inferred from direct assay	11172003	MGI
located in membrane	IDA IDA: Inferred from direct assay	11259273	MGI
located in membrane raft	IDA IDA: Inferred from direct assay	18511518	MGI
located in photoreceptor inner segment	IDA IDA: Inferred from direct assay	25957687	MGI
is active in plasma membrane	IDA IDA: Inferred from direct assay	36423686	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	10394363	MGI
located in presynapse	IDA IDA: Inferred from direct assay	30335140	MGI
located in synapse	IDA IDA: Inferred from direct assay	29490264	MGI
located in vesicle	IDA IDA: Inferred from direct assay	11259273	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Slc2a1 Protein Structure

MFS_GLUT_Class1

0
100
200
300
400
492 a.a.

Protein Preferred Names

Protein Names

solute carrier family 2, facilitated glucose transporter member 1

GT1	glucose transporter type 1, erythrocyte/brain
solute carrier family 2, member 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13157	SLC2A1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13158	Slc2a1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13159	Slc2a1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc2a1	NCBI	NCBI:6513

Name
Email *

	Sorry, but the email address you supplied was invalid.