EPHX2 - epoxide hydrolase 2 Gene

Homo sapiens

Also known as CEH; SEH; ABHD20

Gene ID: 2053 | Gene type: protein coding

About EPHX2

Cytogenetic location: 8p21.2-p21.1 Genomic coordinates (GRCh38): 8:27,491,143-27,545,564 (from NCBI)

This gene has 12 transcripts (splice variants), 204 orthologues, 12 paralogues and is associated with 1 phenotype. Broad expression in kidney (RPKM 34.1), small intestine (RPKM 33.0) and 23 other tissues.

Summary

This gene encodes a member of the Epoxide Hydrolase family. The protein, found in both the cytosol and peroxisomes, binds to specific epoxides and converts them to the corresponding dihydrodiols. Mutations in this gene have been associated with familial hypercholesterolemia. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]

EPHX2 Products(4)

mRNA	Protein	Name
NM_001256482.2	NP_001243411.1	bifunctional epoxide hydrolase 2 isoform 2
NM_001256483.2	NP_001243412.1	bifunctional epoxide hydrolase 2 isoform 3
NM_001256484.2	NP_001243413.1	bifunctional epoxide hydrolase 2 isoform 2
NM_001979.6	NP_001970.2	bifunctional epoxide hydrolase 2 isoform1

EPHX2 Protein Structure

HAD_2

Abhydrolase_1

0
100
200
300
400
500
555 a.a.

Protein Preferred Names

Protein Names

bifunctional epoxide hydrolase 2

epoxide hydratase

Recombinant EPHX2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75227	EPHX2 Protein, Human (sf9, His)	P34913-1/NP_001970.2 (M1-M555)	≥95%

Related Diseases

Diseases

Alias

Hypercholesterolemia, Familial, 1

Hypercholesterolemia	FHCL1
Fhc	Fh
Hyperlipoproteinemia, Type Ii	Hyperlipoproteinemia, Type Iia
Hyper-Low-Density-Lipoproteinemia	Hypercholesterolemic Xanthomatosis, Familial
Ldl Receptor Disorder	Hypercholesterolemia, Susceptibility To
Hypercholesterolemia, Familial, Modifier Of	Hypercholesterolemia, Familial, Due To Ldlr Defect, Modifier Of
Ldl Cholesterol Level Qtl2	Hyperlipoproteinemia Type Ii
Hypercholesterolemia, Familial, Type 1	High Cholesterol
Increased Cholesterol	Low-Density-Lipoid-Type Hyperlipoproteinemia
Pure Hypercholesterolaemia	Ldl - [Low Density Lipoprotein} Hyperlipoproteinemia
Group A Hyperlipidaemia	Pure Hypercholesterinaemia
Cholesterolaemia	Essential Cholesterolaemia
Essential Hypercholesterolaemia	Group A Hyperlipemia
Increased Low Density Lipoprotein	Low-Density-Lipoprotein-Type
Low-Density-Lipoprotein-Type Hyperlipoproteinemia

Familial Hypercholesterolemia

Hyperlipoproteinemia Type Iia	Familial Hyperbetalipoproteinaemia
Familial Hypercholesteremia	Fredrickson Type Iia Hyperlipoproteinemia
Fredrickson Type Iia Lipidaemia	Hyperbetalipoproteinemia
Type Ii Hyperlipidemia	Familial Hypercholesterolæmia
Familial Hypercholesterolaemia	Fh
Hypercholesterolemia Familial	Hyperlipoproteinemia Type Ii
Hypercholesterolemia, Familial

Fetal Hydantoin Syndrome

Dilantin Embryopathy	Phenytoin Embryopathy
Fetal Dihydantoin Syndrome	Phenytoin Embryofetopathy
Dysmorphism Due To Hydantoin

Staphyloenterotoxemia

Staphylococcal Food Poisoning	Staphylococcal Toxaemia Due To Food
Staphyloenterotoxicosis

Commensal Bacterial Infectious Disease

Ritter'S Disease

Staphylococcal Scalded Skin Syndrome	Pemphigus Neonatorum
Ritter Disease	Dermatitis Exfoliativa Neonatorum
Scalded Skin Syndrome	Toxic Epidermal Necrolysis, Subcorneal Type
Generalized Exfoliative Disease	Ssss
Ssss - [Staphylococcal Scalded Skin Syndrome]

Adult Respiratory Distress Syndrome

Acute Respiratory Distress Syndrome	Ards
Non-Cardiogenic Pulmonary Edema	Acute Lung Injury
Respiratory Distress Syndrome, Adult	Shock Lung
Acute Respiratory Distress	Respiratory Distress Syndrome
Adult Rds	Ali
Increased-Permeability Pulmonary Edema	Stiff Lung
Respiratory Distress Syndrome Adult

Pyomyositis

Tropical Pyomyositis	Myositis Tropicans
Myositis Purulenta Tropica	Pm
Suppurative Myositis	Purulent Myositis

Colon Adenocarcinoma

Adenocarcinoma Of Colon	Adenocarcinoma Of The Colon
Colonic Adenocarcinoma

Ichthyosis

Ichthyoses	Non-Syndromic Ichthyosis
Congenital Ichthyosis

Scarlet Fever

Scarlatina

Scarlatina Nos

Intracranial Berry Aneurysm

Familial Aneurysmal Subarachnoid Hemorrhage	Familial Berry Aneurysm
Familial Intracranial Saccular Aneurysm	Saccular Cerebral Aneurysm
Aneurysm, Intracranial Berry	Aneurysmal Subarachnoid Hemorrhage
Aneurysm, Intracranial Berry, 1

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-159157	Anti-inflammatory agent 92	Inhibitor	/	Unkown
HY-RS04439	EPHX2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	EPHX2	VGNC	VGNC:78487
Canis familiaris	EPHX2	VGNC	VGNC:40416
Macaca mulatta	EPHX2	VGNC	VGNC:81392
Bos taurus	EPHX2	VGNC	VGNC:28542
Mus musculus	EPHX2	MGD	MGI:99500
Rattus norvegicus	EPHX2	RGD	RGD:620732
Others	EPHX2	NCBI

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