Enpp3 - ectonucleotide pyrophosphatase/phosphodiesterase 3 Gene

Mus musculus

Also known as CD203c

Gene ID: 209558 | Gene type: protein coding

About Enpp3

Summary

Enables nucleoside-triphosphate diphosphatase activity. Involved in several processes, including basophil activation involved in immune response; negative regulation of mast cell activation involved in immune response; and negative regulation of mast cell proliferation. Located in external side of plasma membrane. Orthologous to human ENPP3 (ectonucleotide pyrophosphatase/phosphodiesterase 3). [provided by Alliance of Genome Resources, Apr 2022]

Enpp3 Products(1)

mRNA	Protein	Name
NM_134005.2	NP_598766.2	ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables nucleoside triphosphate diphosphatase activity	IMP IMP: Inferred from mutant phenotype	25692702	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in ATP metabolic process	IMP IMP: Inferred from mutant phenotype	25692702	MGI
involved in basophil activation involved in immune response	IMP IMP: Inferred from mutant phenotype	25692702	MGI
involved in negative regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	25692702	MGI
involved in negative regulation of mast cell activation involved in immune response	IMP IMP: Inferred from mutant phenotype	25692702	MGI
involved in negative regulation of mast cell proliferation	IMP IMP: Inferred from mutant phenotype	25692702	MGI
involved in phosphate ion homeostasis	IDA IDA: Inferred from direct assay	21490328	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	25692702	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ectonucleotide pyrophosphatase/phosphodiesterase family member 3

E-NPP 3	PD-Ibeta
phosphodiesterase I beta	phosphodiesterase I/nucleotide pyrophosphatase 3

Recombinant Enpp3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P78705	ENPP-3 Protein, Mouse (HEK293, His)	Q6DYE8 (R46-I874)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-147998	Enpp-1-IN-13	Inhibitor	/	Unkown
HY-158791	Enpp-1-IN-21	Inhibitor	/	Unkown
HY-RS04389	ENPP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-169804	ENPP3 Inhibitor 1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Enpp3	NCBI	NCBI:5169
Canis familiaris	Enpp3	NCBI	NCBI:474820
Macaca fascicularis	Enpp3	NCBI	NCBI:102132755

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