ETV3 - ETS variant transcription factor 3 Gene

Homo sapiens

Also known as PE1; METS; PE-1

Gene ID: 2117 | Gene type: protein coding

About ETV3

Cytogenetic location: 1q23.1 Genomic coordinates (GRCh38): 1:157,121,191-157,138,395 (from NCBI)

This gene has 3 transcripts (splice variants), 125 orthologues and 28 paralogues. Ubiquitous expression in skin (RPKM 12.1), gall bladder (RPKM 6.8) and 25 other tissues.

Summary

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ETV3 Products(2)

mRNA	Protein	Name
NM_001145312.3	NP_001138784.1	ETS translocation variant 3 isoform 1
NM_005240.3	NP_005231.1	ETS translocation variant 3 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ETV3 Protein Structure

Ets

0
100
200
300
400
512 a.a.

Protein Preferred Names

Protein Names

ETS translocation variant 3

ETS domain transcriptional repressor PE1

Related Diseases

Diseases

Alias

Hypotrichosis 1

HYPT1	Hhs
Hts	Hypotrichosis Simplex
Hypotrichosis Simplex, Generalized, Hereditary	Hereditary Generalized Hypotrichosis Simplex
Generalized Hypothricosis Simplex	Hypotrichosis Simplex Hereditary
Hypotrichosis, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04566	ETV3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ETV3	VGNC	VGNC:50176
Canis familiaris	ETV3	VGNC	VGNC:53343
Rattus norvegicus	ETV3	RGD	RGD:1311577
Macaca mulatta	ETV3	VGNC	VGNC:99918
Mus musculus	ETV3	MGD	MGI:1350926

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