EVX1 - even-skipped homeobox 1 Gene

Homo sapiens

Also known as EVX-1

Gene ID: 2128 | Gene type: protein coding

About EVX1

Cytogenetic location: 7p15.2 Genomic coordinates (GRCh38): 7:27,242,802-27,247,830 (from NCBI)

This gene has 4 transcripts (splice variants), 195 orthologues and 50 paralogues. Biased expression in prostate (RPKM 2.2), adrenal (RPKM 1.7) and 3 other tissues.

Summary

This gene encodes a member of the even-skipped homeobox family characterized by the presence of a homeodomain closely related to the Drosophila even-skipped (eve) segmentation gene of the pair-rule class. The encoded protein may play an important role as a transcriptional repressor during embryogenesis. [provided by RefSeq, Jul 2008]

EVX1 Products(3)

mRNA	Protein	Name
NM_001304519.2	NP_001291448.1	homeobox even-skipped homolog protein 1 isoform 2
NM_001304520.2	NP_001291449.1	homeobox even-skipped homolog protein 1 isoform 2
NM_001989.5	NP_001980.1	homeobox even-skipped homolog protein 1 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EVX1 Protein Structure

Homeobox

0
100
200
300
407 a.a.

Protein Preferred Names

Protein Names

homeobox even-skipped homolog protein 1

eve, even-skipped homeo box homolog 1

Related Diseases

Diseases

Alias

Hand-Foot-Genital Syndrome

Hand-Foot-Uterus Syndrome	Hfgs
Hfg Syndrome	Hfu Syndrome
HFG	Hfu
Hand Foot Uterus Syndrome	Hand Foot Genital Syndrome

Preaxial Deficiency, Postaxial Polydactyly, And Hypospadias

Guttmacher Syndrome	Preaxial Deficiency, Postaxial Polydactyly And Hypospadias
Autosomal Dominant Preaxial Deficiency, Postaxial Polydactyly, And Hypospadias	Preaxial Deficiency-Postaxial Polydactyly-Hypospadias Syndrome
GUTTS

Cervical Incompetence

Uterine Cervical Incompetence

Congenital Central Hypoventilation Syndrome

Cchs	Haddad Syndrome
Ondine Curse	Ondine Syndrome
Congenital Central Hypoventilation	Congenital Central Alveolar Hypoventilation Syndrome
Congenital Failure Of Autonomic Control	Ondine'S Curse
Primary Alveolar Hypoventilation	Ondine-Hirschsprung Disease
Central Congenital Hypoventilation Syndrome	Congenital Ondine Curse
Idiopathic Congenital Central Alveolar Hypoventilation	Congenital Central Alveolar Hypoventilation-Hirschsprung Disease Syndrome
Ondine-Hirschsprung Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04579	EVX1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	EVX1	VGNC	VGNC:28637
Canis familiaris	EVX1	VGNC	VGNC:40506
Rattus norvegicus	EVX1	RGD	RGD:11434685
Felis catus	EVX1	VGNC	VGNC:61992
Macaca mulatta	EVX1	VGNC	VGNC:108403
Mus musculus	EVX1	MGD	MGI:95461

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