Slc6a6 - solute carrier family 6 (neurotransmitter transporter, taurine), member 6 Gene

Mus musculus

Also known as Taut

Gene ID: 21366 | Gene type: protein coding

About Slc6a6

Summary

Enables beta-alanine transmembrane transporter activity and taurine transmembrane transporter activity. Involved in modulation of chemical synaptic transmission. Acts upstream of or within beta-alanine transport and taurine transport. Located in GABA-ergic synapse. Is integral component of postsynaptic membrane. Is expressed in several structures, including cardiovascular system; central nervous system; placenta; retina; and tooth. Used to study retinitis pigmentosa. Orthologous to human SLC6A6 (solute carrier family 6 member 6). [provided by Alliance of Genome Resources, Apr 2022]

Slc6a6 Products(8)

mRNA	Protein	Name
NM_001410446.1	NP_001397375.1	sodium- and chloride-dependent taurine transporter isoform a
NM_001410447.1	NP_001397376.1	sodium- and chloride-dependent taurine transporter isoform a
NM_001410448.1	NP_001397377.1	sodium- and chloride-dependent taurine transporter isoform b
NM_001410449.1	NP_001397378.1	sodium- and chloride-dependent taurine transporter isoform c precursor
NM_001410450.1	NP_001397379.1	sodium- and chloride-dependent taurine transporter isoform d precursor
NM_001410451.1	NP_001397380.1	sodium- and chloride-dependent taurine transporter isoform e
NM_001410452.1	NP_001397381.1	sodium- and chloride-dependent taurine transporter isoform e
NM_009320.5	NP_033346.2	sodium- and chloride-dependent taurine transporter isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables amino acid:sodium symporter activity	IDA IDA: Inferred from direct assay	1465453	MGI
enables gamma-aminobutyric acid:sodium:chloride symporter activity	IDA IDA: Inferred from direct assay	30270321	MGI
enables taurine transmembrane transporter activity	IDA IDA: Inferred from direct assay	1465453	MGI
enables taurine:sodium symporter activity	IDA IDA: Inferred from direct assay	1465453	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	12824447	MGI
involved in modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	12824447	MGI
acts upstream of or within taurine transmembrane transport	IDA IDA: Inferred from direct assay	1465453	MGI
acts upstream of or within taurine transmembrane transport	IMP IMP: Inferred from mutant phenotype	11772953	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	12824447	MGI
is active in GABA-ergic synapse	IMP IMP: Inferred from mutant phenotype	12824447	MGI
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	17962336	MGI
is active in postsynaptic membrane	IMP IMP: Inferred from mutant phenotype	17962336	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

sodium- and chloride-dependent taurine transporter

solute carrier family 6 member 6

taurine/beta-alanine transporter

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13317	SLC6A6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS16229	Slc6a6 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc6a6	NCBI	NCBI:6533

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