2. Gene
  3. Mgat2 - mannoside acetylglucosaminyltransferase 2 Gene

Mgat2 - mannoside acetylglucosaminyltransferase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as GNT2; CDGS2; GNT-II; GLCNACTII

Gene ID: 217664 | Gene type: protein coding

About Mgat2

Chromosome 12: 69,230,931-69,233,544 forward strand.GRCm39:CM001005.3

This gene has 1 transcript (splice variant), 178 orthologues and is associated with 40 phenotypes.

Summary

Enables alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity. Acts upstream of or within protein N-linked glycosylation via asparagine. Predicted to be located in Golgi apparatus. Predicted to be active in Golgi membrane. Is expressed in several structures, including alimentary system; cranium; integumental system; sensory organ; and telencephalon. Used to study congenital disorder of glycosylation type IIa. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIa. Orthologous to human MGAT2 (alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Mgat2 Products(1)

mRNA Protein Name
NM_146035.2 NP_666147.1 alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Mgat2 Protein Structure

MGAT2

MGAT2: pfam05060 (86 - 434)

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  • 442 a.a.
Protein Preferred Names Protein Names

alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II

beta-1,2-N-acetylglucosaminyltransferase II

glcNAc-T II

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-159422 S-309309 Inhibitor / Unkown
HY-U00430 MGAT2-IN-2 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mgat2 NCBI NCBI:4247