S-309309

Cat. No.: HY-159422: FAQs
Data Sheet Handling Instructions

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S-309309 is an orally active and selective MGAT2 inhibitor. S-309309 can be used in metabolism-related research.

For research use only. We do not sell to patients.

S-309309 Chemical Structure

CAS No. : 2267352-04-3

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ACAT1 ACAT2 MGAT2 ACAT

Biological Activity
Purity & Documentation
References
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Description

S-309309 is an orally active and selective MGAT2 inhibitor. S-309309 can be used in metabolism-related research^[1].

IC₅₀ & Target

MGAT2

In Vivo

S-309309 (3 mg/kg, p.o., b.i.d., 6-13 weeks) inhibits food intake and body weight gain in DIO mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	High fat diet (HFD)-induced obesity (DIO) mice^[1]
Dosage:	3 mg/kg
Administration:	p.o., b.i.d., 6-13 weeks
Result:	Decreased in insulin resistance index, hepatic triglycerides content, plasma alanine aminotransferase and aspartate aminotransferase level, and gene expression related to fibrosis. Enhanced energy expenditure and upregulation of intestinal gene expression related to long-chain fatty acid beta oxidation.

Molecular Weight

517.51

Formula

C₂₃H₂₁F₂N₅O₅S

CAS No.

2267352-04-3

SMILES

FC1=CC(F)=CC2=C1[C@]3(NC(C4=C(NC(CS(C)(=O)=O)=O)N(C5=CC=C(C)C=N5)N=C4C3)=O)CCO2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Miyano T, et al. The Continuous and Reversible Transformation of the Polymorphs of an MGAT2 Inhibitor (S-309309) from the Anhydrate to the Hydrate in Response to Relative Humidity. Pharmaceutics. 2024 Jul 17;16(7):949. [Content Brief]

[2]. YOSHIKI RYO, et al. 1649-P: S-309309, a Novel MGAT2 Inhibitor, Enhances Intestinal Fatty Acid Beta Oxidation and Provides Metabolic Benefits in DIO Mice. Diabetes, 2024, 73(Supplement_1).

S-309309 Related Classifications

Metabolic Disease

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

S-3093092267352-04-3S309309S 309309AcyltransferaseDiacylglycerol acyltransferaseDiglyceride acyltransferaseacyl-CoA:cholesterol acyltransferasemono- acylglycerol acyltransferaseDIOmetabolismfatty acid beta oxidationHFDInhibitorinhibitorinhibit

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