2. Gene
  3. Tgm2 - transglutaminase 2, C polypeptide Gene

Tgm2 - transglutaminase 2, C polypeptide Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as TG2; tTG; G[a]h; tTGas; TGase2

Gene ID: 21817 | Gene type: protein coding

About Tgm2

Summary

Enables protein-glutamine gamma-glutamyltransferase activity. Involved in cellular calcium ion homeostasis; positive regulation of cell adhesion; and regulation of apoptotic cell clearance. Acts upstream of or within branching involved in salivary gland morphogenesis and salivary gland cavitation. Located in collagen-containing extracellular matrix. Is expressed in several structures, including alimentary system; central nervous system; cranium; genitourinary system; and sensory organ. Used to study maturity-onset diabetes of the young. Orthologous to human TGM2 (transglutaminase 2). [provided by Alliance of Genome Resources, Apr 2022]

Tgm2 Products(1)

mRNA Protein Name
NM_009373.3 NP_033399.1 protein-glutamine gamma-glutamyltransferase 2
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein-glutamine gamma-glutamyltransferase activity IMP
IMP: Inferred from mutant phenotype
11113189 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within branching involved in salivary gland morphogenesis IMP
IMP: Inferred from mutant phenotype
15970210 MGI
involved in negative regulation of endoplasmic reticulum calcium ion concentration IMP
IMP: Inferred from mutant phenotype
24349085 MGI
involved in positive regulation of cell adhesion IMP
IMP: Inferred from mutant phenotype
11274171 MGI
involved in positive regulation of mitochondrial calcium ion concentration IMP
IMP: Inferred from mutant phenotype
24349085 MGI
involved in regulation of apoptotic cell clearance IMP
IMP: Inferred from mutant phenotype
12810961 MGI
acts upstream of or within salivary gland cavitation IMP
IMP: Inferred from mutant phenotype
15970210 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein-glutamine gamma-glutamyltransferase 2

C polypeptide

TG(C)

TGC

TGase C

TGase II

TGase-2

isopeptidase TGM2

protein-glutamine deamidase TGM2

protein-glutamine dopaminyltransferase TGM2

protein-glutamine histaminyltransferase TGM2

protein-glutamine noradrenalinyltransferase TGM2

protei

Recombinant Tgm2 Proteins

Cat. No. Product Name Accession Purity
HY-P71132 TGM2/Transglutaminase 2 Protein, Mouse (HEK293, His) P21981 (A2-A686) ≥95%
HY-P78361 TGM2/Transglutaminase 2 Protein, Mouse (His) P21981 (A2-A686) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-117678 TG-2-IN-1 Inhibitor ≥98.0% Unkown
HY-12589 ZM39923 hydrochloride Inhibitor 98.19% Unkown
HY-RS14459 TGM2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-12589A ZM39923 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tgm2 NCBI NCBI:7052