Tnfrsf1a - tumor necrosis factor receptor superfamily, member 1a Gene

Mus musculus

Also known as FPF; p55; TNF-R; TNFAR; TNFRI; Tnfr1; p55-R; CD120a; TNF-R1; TNFR60; Tnfr-2; TNF-R-I; TNF-R55; TNFRp55; TNF-alphaR1; TNFalpha-R1

Gene ID: 21937 | Gene type: protein coding

About Tnfrsf1a

Summary

This gene encodes a member of the TNF Receptor Superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation, which plays a role in cell survival, Apoptosis, and inflammation. Proteolytic processing of the encoded receptor results in release of the soluble form of the receptor, which can interact with free tumor necrosis factor alpha to inhibit inflammation. Mice lacking a functional copy of this gene exhibit impaired immune function. [provided by RefSeq, Sep 2016]

Tnfrsf1a Products(1)

mRNA	Protein	Name
NM_011609.4	NP_035739.2	tumor necrosis factor receptor superfamily member 1A precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11374864	MGI
enables signaling receptor activity	IDA IDA: Inferred from direct assay	1647956	MGI
enables tumor necrosis factor receptor activity	IDA IDA: Inferred from direct assay	1647956	MGI
enables tumor necrosis factor receptor activity	IGI IGI: Inferred from genetic interaction	14985352	MGI
enables tumor necrosis factor receptor activity	IMP IMP: Inferred from mutant phenotype	11588035	MGI
enables tumor necrosis factor receptor activity	IPI IPI: Inferred from physical interaction	1645445	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in aortic valve development	IGI IGI: Inferred from genetic interaction	26491108	MGI
acts upstream of or within cell surface receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	9551933	MGI
acts upstream of or within cytokine-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	11588035	MGI
acts upstream of or within defense response	IMP IMP: Inferred from mutant phenotype	8387893	MGI
acts upstream of or within defense response to bacterium	IMP IMP: Inferred from mutant phenotype	9324362	MGI
acts upstream of or within inflammatory response	IMP IMP: Inferred from mutant phenotype	9551933	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage	IMP IMP: Inferred from mutant phenotype	17242187	MGI
involved in negative regulation of cardiac muscle hypertrophy	IGI IGI: Inferred from genetic interaction	26491108	MGI
involved in negative regulation of extracellular matrix constituent secretion	IGI IGI: Inferred from genetic interaction	26491108	MGI
involved in positive regulation of amide metabolic process	IGI IGI: Inferred from genetic interaction	14985352	MGI
involved in positive regulation of apoptotic process involved in morphogenesis	IGI IGI: Inferred from genetic interaction	26491108	MGI
involved in positive regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	7525730	MGI
involved in positive regulation of cellular metabolic process	IGI IGI: Inferred from genetic interaction	14985352	MGI
involved in positive regulation of execution phase of apoptosis	IGI IGI: Inferred from genetic interaction	10702415	MGI
involved in positive regulation of execution phase of apoptosis	IMP IMP: Inferred from mutant phenotype	10678933	MGI
acts upstream of or within positive regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	11588035	MGI
involved in positive regulation of lipid metabolic process	IGI IGI: Inferred from genetic interaction	14985352	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	11588035	MGI
involved in pulmonary valve development	IGI IGI: Inferred from genetic interaction	26491108	MGI
involved in regulation of membrane lipid metabolic process	IGI IGI: Inferred from genetic interaction	14985352	MGI
acts upstream of or within regulation of tumor necrosis factor-mediated signaling pathway	IGI IGI: Inferred from genetic interaction	25220458	MGI
acts upstream of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	11588035	MGI
involved in tumor necrosis factor-mediated signaling pathway	IGI IGI: Inferred from genetic interaction	14985352	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	21410936	MGI
located in membrane raft	IDA IDA: Inferred from direct assay	17010968	MGI
is active in plasma membrane	IDA IDA: Inferred from direct assay	1647956	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

tumor necrosis factor receptor superfamily member 1A

TNF receptor alpha chain	TNF-RI
TNF-alpha-R1	TNFR-I
p60	tumor necrosis factor receptor 1
tumor necrosis factor receptor type I

Recombinant Tnfrsf1a Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72443	TNF RI/TNFRSF1A Protein, Mouse	P25118 (I22-A212)	≥95%
HY-P73449	TNF RI/TNFRSF1A Protein, Mouse (HEK293, Fc)	P25118 (M1-A212)	≥95%
HY-P73450	TNF RI/TNFRSF1A Protein, Mouse (HEK293, His)	P25118 (M1-A212)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-138779	ICCB-19 hydrochloride		99.24%	Unkown
HY-N4323	14-Deoxyandrographolide	Inhibitor	99.47%	Unkown
HY-RS14810	TNFRSF1A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tnfrsf1a	NCBI	NCBI:7132
Macaca fascicularis	Tnfrsf1a	NCBI	NCBI:102135285
Rattus norvegicus	Tnfrsf1a	NCBI	NCBI:25625

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