2. Gene
  3. Cd40lg - CD40 ligand Gene

Cd40lg - CD40 ligand Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as IGM; IMD3; Ly62; TRAP; gp39; CD154; Cd40l; HIGM1; Ly-62; T-BAM; CD40-L; Tnfsf5; Tnlg8b

Gene ID: 21947 | Gene type: protein coding

About Cd40lg

Summary

Predicted to enable CD40 receptor binding activity and Integrin binding activity. Involved in isotype switching. Acts upstream of or within B cell differentiation and regulation of immunoglobulin production. Located in external side of plasma membrane. Is expressed in Meckel's cartilage; dorsal root ganglion; and limb. Used to study inflammatory bowel disease and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; artery disease (multiple); autoimmune disease (multiple); combined T cell and B cell immunodeficiency (multiple); and hematologic Cancer (multiple). Orthologous to human CD40LG (CD40 ligand). [provided by Alliance of Genome Resources, Apr 2022]

Cd40lg Products(1)

mRNA Protein Name
NM_011616.3 NP_035746.2 CD40 ligand
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within B cell differentiation IGI
IGI: Inferred from genetic interaction
14647274 MGI
acts upstream of or within immunoglobulin production IGI
IGI: Inferred from genetic interaction
15485634 MGI
involved in isotype switching IDA
IDA: Inferred from direct assay
7529792 MGI
acts upstream of or within regulation of immunoglobulin production IDA
IDA: Inferred from direct assay
12958312 MGI
Cellular Component GO Annotation Evidence Reference Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
17082577 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

CD40 ligand

T-cell antigen Gp39

TNF-related activation protein

tumor necrosis factor ligand 8b

tumor necrosis factor ligand superfamily member 5

Recombinant Cd40lg Proteins

Cat. No. Product Name Accession Purity
HY-P70808 CD40L/CD154/TRAP Protein, Mouse (HEK293, His) P27548 (M112-L260) ≥95%
HY-P72908 CD40L/CD154/TRAP Protein, Mouse (HEK293, Fc) P27548 (G115-L260) ≥95%
HY-P78271 CD40L/CD154/TRAP Trimer Protein, Mouse (HEK293, Fc) P27548 (M112-L260) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02247 CD40LG Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cd40lg NCBI NCBI:959
Leporidae Cd40lg NCBI
Macaca mulatta Cd40lg NCBI NCBI:574160