Tfrc - transferrin receptor Gene

Mus musculus

Also known as TR; TFR; p90; CD71; TFR1; Trfr; Mtvr1; 2610028K12Rik; E430033M20Rik

Gene ID: 22042 | Gene type: protein coding

About Tfrc

Summary

This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Mice that are deficient in this receptor show impaired erythroid development and abnormal iron homeostasis. [provided by RefSeq, Sep 2015]

Tfrc Products(2)

mRNA	Protein	Name
NM_001357298.1	NP_001344227.1	transferrin receptor protein 1
NM_011638.4	NP_035768.1	transferrin receptor protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16893896	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cellular response to leukemia inhibitory factor	IEP IEP: Inferred from expression pattern	20439489	MGI
acts upstream of or within intracellular iron ion homeostasis	IMP IMP: Inferred from mutant phenotype	10192390	MGI
involved in osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	19252502	MGI
involved in positive regulation of B cell proliferation	IDA IDA: Inferred from direct assay	26642240	MGI
involved in positive regulation of T cell proliferation	IDA IDA: Inferred from direct assay	26642240	MGI
involved in positive regulation of bone resorption	IDA IDA: Inferred from direct assay	19252502	MGI
involved in regulation of postsynaptic membrane neurotransmitter receptor levels	IDA IDA: Inferred from direct assay	26880306	MGI
involved in regulation of postsynaptic membrane neurotransmitter receptor levels	IEP IEP: Inferred from expression pattern	26880306	MGI
involved in regulation of postsynaptic membrane neurotransmitter receptor levels	IMP IMP: Inferred from mutant phenotype	26880306	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of HFE-transferrin receptor complex	IDA IDA: Inferred from direct assay	16893896	MGI
located in cell surface	IDA IDA: Inferred from direct assay	17716972	MGI
located in clathrin-coated pit	IDA IDA: Inferred from direct assay	18434600	MGI
located in early endosome	IDA IDA: Inferred from direct assay	26432893	MGI
located in endosome	IDA IDA: Inferred from direct assay	11092755	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	20424607	MGI
located in extracellular exosome	IDA IDA: Inferred from direct assay	19724054	MGI
located in membrane	IMP IMP: Inferred from mutant phenotype	20080761	MGI
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	10444069	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	10444069	MGI
is active in postsynapse	IDA IDA: Inferred from direct assay	26880306	MGI
located in recycling endosome	IDA IDA: Inferred from direct assay	23395379	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transferrin receptor protein 1

mammary tumor virus receptor 1

Recombinant Tfrc Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72455	TFRC Protein, Mouse (HEK293, His)	Q62351 (C89-F763)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14431	TFRC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990051	Delpacibart	Inhibitor	96.11%	Unkown
HY-P990780	Zeleciment		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tfrc	NCBI	NCBI:7037
Macaca fascicularis	Tfrc	NCBI	NCBI:102136007

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