2. Gene
  3. FCER1A - Fc epsilon receptor Ia Gene

FCER1A - Fc epsilon receptor Ia Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as FCE1A; FcERI; FCERIA

Gene ID: 2205 | Gene type: protein coding

About FCER1A

Cytogenetic location: 1q23.2 Genomic coordinates (GRCh38): 1:159,283,575-159,308,202 (from NCBI)

This gene has 3 transcripts (splice variants), 196 orthologues and 17 paralogues. Broad expression in skin (RPKM 12.7), esophagus (RPKM 10.4) and 20 other tissues.

Summary

The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Aug 2011]

FCER1A Products(4)

mRNA Protein Name
NM_001387280.1 NP_001374209.1 high affinity immunoglobulin epsilon receptor subunit alpha isoform 1 precursor
NM_001387281.1 NP_001374210.1 high affinity immunoglobulin epsilon receptor subunit alpha isoform 3 precursor
NM_001387282.1 NP_001374211.1 high affinity immunoglobulin epsilon receptor subunit alpha isoform 2 precursor
NM_002001.4 NP_001992.1 high affinity immunoglobulin epsilon receptor subunit alpha isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables IgE binding IDA
IDA: Inferred from direct assay
10917520 GOA
enables high-affinity IgE receptor activity IDA
IDA: Inferred from direct assay
8114916 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10917520 GOA
Biological Process GO Annotation Evidence Reference Source
involved in eosinophil degranulation IDA
IDA: Inferred from direct assay
8114916 GOA
involved in mast cell degranulation IMP
IMP: Inferred from mutant phenotype
8551243 GOA
involved in type 2 immune response IDA
IDA: Inferred from direct assay
8114916 GOA
involved in type I hypersensitivity IMP
IMP: Inferred from mutant phenotype
8551243 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cell surface IDA
IDA: Inferred from direct assay
1535625 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
8114916 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FCER1A Protein Structure

Ig_2

Ig_2: Immunoglobulin domain (30 - 104)

Ig_2

Ig_2: Immunoglobulin domain (114 - 194)

  • 0
  • 100
  • 200
  • 257 a.a.
Protein Preferred Names Protein Names

high affinity immunoglobulin epsilon receptor subunit alpha

Fc IgE receptor, alpha polypeptide

FCER1A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
FCER1A P12319 MESD Homo sapiens Q14696
Y2H Prey Pooling
32296183
Intra
FCER1A P12319 MESD Homo sapiens Q14696
Validated Y2H
32296183
Intra
FCER1A P12319 MESD Homo sapiens Q14696
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FCER1A Proteins

Cat. No. Product Name Accession Purity
HY-P72191 Fc epsilon RIA/FCER1A Protein, Human (His-SUMO) P12319 (V26-Q205) ≥95%

Related Diseases

Diseases Alias
Chronic Spontaneous Urticaria

Chronic Idiopathic Urticaria
Chronic Urticaria

Urticaria Chronic

Chronic Spontaneous Urticaria

Chronic Ordinary Urticaria
Physical Urticaria

Symptomatic Dermographism
Urticaria

Nettle Rash

Hives

Wheal

Urticaria Nos
Dermatographia

Dermatographic Urticaria

Dermographism

Symptomatic Dermographism

Urticaria Factitia

Factitious Urticaria

Dermatographism
Allergic Rhinitis

Hay Fever

Allergic Rhinitis, Susceptibility To

ALRH

Atopic Rhinitis

Seasonal Allergic Rhinitis

Non-Seasonal Allergic Rhinitis

Perenial Allergic Rhinitis

Pollenosis

Rhinitis Allergic Seasonal

Rhinitis, Allergic, Perennial

Allergic Rhinitis, Cause Unspecified

Pollinosis

Pollen Allergy

Allergy Nos Due To Pollen

Summer Catarrh

Other Seasonal Allergic Rhinitis
Amoxicillin Allergy
Chronic Inducible Urticaria
Cholinergic Urticaria
Allergic Urticaria
Trombiculiasis
Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus
Dermatitis, Atopic

Atopic Dermatitis

Atopic Eczema

Dermatitis, Atopic, Susceptibility To, 1

Atod

Eczema, Atopic

Dermatitis, Atopic 1

Allergic Dermatitis

Atopic Neurodermatitis

Besnier'S Prurigo

Dermatitis, Atopic, 1

Dermatitis Atopic

Eczema

Besnier Prurigo
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04822 FCER1A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus FCER1A VGNC VGNC:28930
Felis catus FCER1A VGNC VGNC:62208
Canis familiaris FCER1A VGNC VGNC:40801
Macaca mulatta FCER1A VGNC VGNC:72628
Mus musculus FCER1A MGD MGI:95494
Rattus norvegicus FCER1A RGD RGD:2597
Others FCER1A NCBI