OPN5 - opsin 5 Gene

Homo sapiens

Also known as PGR12; GPR136; GRP136; TMEM13

Gene ID: 221391 | Gene type: protein coding

About OPN5

Cytogenetic location: 6p12.3 Genomic coordinates (GRCh38): 6:47,782,032-47,826,381 (from NCBI)

This gene has 6 transcripts (splice variants), 208 orthologues and 9 paralogues. Restricted expression toward testis (RPKM 1.6).

Summary

Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This opsin gene is expressed in the eye, brain, testes, and spinal cord. This gene belongs to the seven-exon subfamily of mammalian opsin genes that includes peropsin (RRH) and retinal G protein coupled receptor (RGR). Like these Other seven-exon opsin genes, this family member may encode a protein with photoisomerase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]

OPN5 Products(1)

mRNA	Protein	Name
NM_181744.4	NP_859528.1	opsin-5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 11-cis retinal binding	IMP IMP: Inferred from mutant phenotype	22043319	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to UV-A	IDA IDA: Inferred from direct assay	31380578	GOA
involved in phototransduction, UV	IMP IMP: Inferred from mutant phenotype	22043319	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	30168605	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	31380578	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OPN5 Protein Structure

7tm_1

0
100
200
300
354 a.a.

Protein Preferred Names

Protein Names

opsin-5

G-protein coupled receptor 136

Related Diseases

Diseases

Alias

Galloway-Mowat Syndrome

Galloway Mowat Syndrome	Galloway Syndrome
Hiatal Hernia-Microcephaly-Nephrosis, Galloway Type	Microcephaly Nephrosis Syndrome
Microcephaly, Hiatal Hernia, And Nephrotic Syndrome	Nephrosis Neuronal Dysmigration Syndrome
Microcephaly-Hiatus Hernia-Nephrotic Syndrome	Nephrosis-Neuronal Dysmigration Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09800	OPN5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	OPN5	VGNC	VGNC:75439
Felis catus	OPN5	VGNC	VGNC:63969
Mus musculus	OPN5	MGD	MGI:2662912
Bos taurus	OPN5	VGNC	VGNC:32438
Canis familiaris	OPN5	VGNC	VGNC:44131
Rattus norvegicus	OPN5	RGD	RGD:727869

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