TMED4 - transmembrane p24 trafficking protein 4 Gene

Homo sapiens

Also known as HNLF; ERS25; p24a3; GMP25iso; p24alpha3

Gene ID: 222068 | Gene type: protein coding

About TMED4

Cytogenetic location: 7p13 Genomic coordinates (GRCh38): 7:44,577,894-44,582,231 (from NCBI)

This gene has 5 transcripts (splice variants), 212 orthologues and 8 paralogues. Ubiquitous expression in thyroid (RPKM 37.8), small intestine (RPKM 27.8) and 25 other tissues.

Summary

Involved in positive regulation of I-kappaB kinase/NF-kappaB signaling. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Predicted to be active in several cellular components, including COPII-coated ER to Golgi transport vesicle; Golgi apparatus; and endoplasmic reticulum-Golgi intermediate compartment. [provided by Alliance of Genome Resources, Apr 2022]

TMED4 Products(6)

mRNA	Protein	Name
NM_001303058.2	NP_001289987.1	transmembrane emp24 domain-containing protein 4 isoform 2 precursor
NM_001303059.2	NP_001289988.1	transmembrane emp24 domain-containing protein 4 isoform 3 precursor
NM_001303060.2	NP_001289989.1	transmembrane emp24 domain-containing protein 4 isoform 4
NM_001303061.2	NP_001289990.1	transmembrane emp24 domain-containing protein 4 isoform 5
NM_001303062.2	NP_001289991.1	transmembrane emp24 domain-containing protein 4 isoform 5
NM_182547.4	NP_872353.2	transmembrane emp24 domain-containing protein 4 isoform 1 precursor

TMED4 Protein Structure

EMP24_GP25L

0
100
200
227 a.a.

Protein Preferred Names

Protein Names

transmembrane emp24 domain-containing protein 4

endoplasmic reticulum stress-response protein 25 kDa

Recombinant TMED4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77242	TMED4 Protein, Human (HEK293, His)	Q7Z7H5 (L30-R194)	≥95%
HY-P77243	TMED4 Protein, Human (HEK293, Fc)	Q7Z7H5-1 (L30-R194)	≥95%

Related Diseases

Diseases

Alias

Ceroid Lipofuscinosis, Neuronal, 8

Neuronal Ceroid Lipofuscinosis 8	CLN8
Cln8 Disease	Epilepsy Mental Deterioration Finnish Type
Northern Epilepsy	Cln8 Disease, Epmr
Cln8 Disease, Northern Epilepsy Variant	Cln8 Disease, Late Infantile
Ceroid Lipofuscinosis Neuronal 8	Ncl, Northern Epilepsy Variant
Neuronal Ceroid Lipofuscinosis, Northern Epilepsy Variant	Progressive Epilepsy - Intellectual Disability, Finnish Type
Progressive Epilepsy-Intellectual Disability Syndrome, Finnish Type	Turkish Variant Late Infantile Ncl
Ceroid Lipofuscinosis, Neuronal 8	Lipofuscinosis, Ceroid, Neuronal, Type 8
Northern Epilepsy Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14638	TMED4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TMED4	VGNC	VGNC:35937
Macaca mulatta	TMED4	VGNC	VGNC:79352
Mus musculus	TMED4	MGD	MGI:1915070
Rattus norvegicus	TMED4	RGD	RGD:1306319
Canis familiaris	TMED4	VGNC	VGNC:47439
Felis catus	TMED4	VGNC	VGNC:66249
Others	TMED4	NCBI

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