LRWD1 - leucine rich repeats and WD repeat domain containing 1 Gene

Homo sapiens

Also known as ORCA; CENP-33

Gene ID: 222229 | Gene type: protein coding

About LRWD1

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:102,464,984-102,473,168 (from NCBI)

This gene has 9 transcripts (splice variants), 188 orthologues and 1 paralogue. Biased expression in testis (RPKM 101.1) and bone marrow (RPKM 5.9).

Summary

The protein encoded by this gene interacts with components of the origin recognition complex (ORC) and regulates the formation of the prereplicative complex. The encoded protein stabilizes the ORC and therefore aids in DNA replication. This protein is required for the G1/S phase transition of the cell cycle. In addition, the encoded protein binds to trimethylated histone H3 in heterochromatin and recruits the ORC and lysine methyltransferases, which help maintain the repressive heterochromatic state. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

LRWD1 Products(2)

mRNA	Protein	Name
NM_001317721.2	NP_001304650.1	leucine-rich repeat and WD repeat-containing protein 1 isoform 2
NM_152892.3	NP_690852.1	leucine-rich repeat and WD repeat-containing protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chromatin binding	IDA IDA: Inferred from direct assay	20932478	GOA
enables methyl-CpG binding	IDA IDA: Inferred from direct assay	21029866	GOA
enables methylated histone binding	IDA IDA: Inferred from direct assay	21029866	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20932478	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in chromatin organization	IMP IMP: Inferred from mutant phenotype	20932478	GOA
involved in establishment of protein localization to chromatin	IDA IDA: Inferred from direct assay	20932478	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromosome, telomeric region	IDA IDA: Inferred from direct assay	20932478	GOA
located in kinetochore	IDA IDA: Inferred from direct assay	20813266	GOA
part of nuclear origin of replication recognition complex	IDA IDA: Inferred from direct assay	20932478	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18445686	GOA
located in pericentric heterochromatin	IDA IDA: Inferred from direct assay	20932478	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LRWD1 Protein Structure

LRR_8

WD40

0
100
200
300
400
500
600
647 a.a.

Protein Preferred Names

Protein Names

leucine-rich repeat and WD repeat-containing protein 1

ORC-associated protein

Related Diseases

Diseases

Alias

Skin Angiosarcoma

Angiosarcoma Of Skin	Hemangiosarcoma Of The Skin
Haemangiosarcoma Of Skin	Lymphangiosarcoma Of Skin
Cutaneous Angiosarcoma	Malignant Haemangioendothelioma Of Skin

Embryonal Testis Carcinoma

Testicular Embryonal Carcinoma	Embryonal Carcinoma Of Testis
Embryonal Carcinoma Of The Testis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07849	LRWD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	LRWD1	MGD	MGI:1918985
Felis catus	LRWD1	VGNC	VGNC:63320
Macaca mulatta	LRWD1	VGNC	VGNC:74332
Bos taurus	LRWD1	VGNC	VGNC:31048
Rattus norvegicus	LRWD1	RGD	RGD:1359442
Canis familiaris	LRWD1	VGNC	VGNC:42835

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