Yap1 - yes-associated protein 1 Gene

Mus musculus

Also known as Yap; Yki; Yap65; Yorkie

Gene ID: 22601 | Gene type: protein coding

About Yap1

Chromosome 9: 7,932,000-8,004,597 reverse strand.GRCm39:CM001002.3

This gene has 10 transcripts (splice variants), 219 orthologues, 1 paralogue and is associated with 30 phenotypes. Ubiquitous expression in limb E14.5 (RPKM 25.3), bladder adult (RPKM 22.8) and 28 other tissues.

Summary

This gene encodes a protein which binds to the SH3 domain of the Yes proto-oncogene product, a tyrosine kinase. This protein contains a WW domain, consisting of four conserved aromatic Amino acids including two tryptophan residues. This conserved WW domain is found in various structural, regulatory and signaling molecules in various species, and may play a role in protein-protein interaction. Following cellular damage, phosphorylation of this encoded protein may suppress Apoptosis. This protein may be involved in malignant transformation in Cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]

Yap1 Products(2)

mRNA	Protein	Name
NM_009534.3	NP_033560.1	transcriptional coactivator YAP1 isoform 2
NM_001171147.1	NP_001164618.1	transcriptional coactivator YAP1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	20516196	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	19952108	MGI
enables proline-rich region binding	IPI IPI: Inferred from physical interaction	9305852	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11278685	MGI
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	16332960	MGI
enables transcription coactivator activity	IMP IMP: Inferred from mutant phenotype	26902285	MGI
enables transcription factor binding	IPI IPI: Inferred from physical interaction	19952108	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of blastocyst development	IMP IMP: Inferred from mutant phenotype	26902285	MGI
acts upstream of or within bud elongation involved in lung branching	IMP IMP: Inferred from mutant phenotype	25043473	MGI
acts upstream of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	17980593	MGI
involved in cardiac muscle tissue regeneration	IMP IMP: Inferred from mutant phenotype	23918388	MGI
acts upstream of or within cell morphogenesis	IMP IMP: Inferred from mutant phenotype	20516196	MGI
acts upstream of cell population proliferation	IDA IDA: Inferred from direct assay	17980593	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	19853564	MGI
acts upstream of or within cellular response to retinoic acid	IDA IDA: Inferred from direct assay	21385842	MGI
acts upstream of or within embryonic heart tube morphogenesis	IGI IGI: Inferred from genetic interaction	18332127	MGI
acts upstream of enterocyte differentiation	IDA IDA: Inferred from direct assay	17980593	MGI
acts upstream of epithelial cell proliferation	IDA IDA: Inferred from direct assay	17980593	MGI
involved in epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	29400695	MGI
acts upstream of extrinsic apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	17980593	MGI
acts upstream of glandular epithelial cell differentiation	IDA IDA: Inferred from direct assay	17980593	MGI
involved in heart process	IMP IMP: Inferred from mutant phenotype	23918388	MGI
acts upstream of or within hippo signaling	IGI IGI: Inferred from genetic interaction	18369314	MGI
involved in interleukin-6-mediated signaling pathway	IDA IDA: Inferred from direct assay	25731159	MGI
involved in intestinal epithelial cell development	IDA IDA: Inferred from direct assay	25731159	MGI
acts upstream of intestinal epithelial cell differentiation	IDA IDA: Inferred from direct assay	17980593	MGI
acts upstream of or within keratinocyte differentiation	IGI IGI: Inferred from genetic interaction	18369314	MGI
acts upstream of or within keratinocyte differentiation	IMP IMP: Inferred from mutant phenotype	18369314	MGI
acts upstream of or within lateral mesoderm development	IGI IGI: Inferred from genetic interaction	18332127	MGI
acts upstream of or within lung epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	25043473	MGI
acts upstream of or within negative regulation of epithelial cell differentiation	IDA IDA: Inferred from direct assay	17980593	MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	17980593	MGI
acts upstream of or within negative regulation of stem cell differentiation	IDA IDA: Inferred from direct assay	20516196	MGI
acts upstream of or within notochord development	IGI IGI: Inferred from genetic interaction	18332127	MGI
acts upstream of organ growth	IDA IDA: Inferred from direct assay	17980593	MGI
involved in organ growth	IMP IMP: Inferred from mutant phenotype	29400695	MGI
acts upstream of or within paraxial mesoderm development	IGI IGI: Inferred from genetic interaction	18332127	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	26902285	MGI
involved in positive regulation of Notch signaling pathway	IDA IDA: Inferred from direct assay	25731159	MGI
acts upstream of or within positive regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	17980593	MGI
involved in positive regulation of cardiac muscle cell proliferation	IDA IDA: Inferred from direct assay	23918388	MGI
acts upstream of or within positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	17980593	MGI
acts upstream of or within positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	19853564	MGI
acts upstream of or within positive regulation of epithelial cell proliferation	IDA IDA: Inferred from direct assay	17980593	MGI
acts upstream of or within positive regulation of organ growth	IDA IDA: Inferred from direct assay	17980593	MGI
involved in positive regulation of protein localization to nucleus	IMP IMP: Inferred from mutant phenotype	21145499	MGI
acts upstream of or within positive regulation of stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	20516196	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	20516196	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11358867	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	16207754	MGI
acts upstream of or within regulation of canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	23974041	MGI
acts upstream of or within regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	19004856	MGI
acts upstream of or within regulation of gene expression	IGI IGI: Inferred from genetic interaction	27288457	MGI
acts upstream of or within regulation of keratinocyte proliferation	IMP IMP: Inferred from mutant phenotype	18369314	MGI
acts upstream of or within regulation of metanephric nephron tubule epithelial cell differentiation	IGI IGI: Inferred from genetic interaction	23974041	MGI
acts upstream of or within regulation of stem cell proliferation	IDA IDA: Inferred from direct assay	19952108	MGI
acts upstream of or within regulation of stem cell proliferation	IGI IGI: Inferred from genetic interaction	25433207	MGI
acts upstream of or within regulation of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	19853564	MGI
acts upstream of or within somatic stem cell population maintenance	IDA IDA: Inferred from direct assay	17980593	MGI
involved in tissue homeostasis	IMP IMP: Inferred from mutant phenotype	23918388	MGI
acts upstream of trophectodermal cell differentiation	IMP IMP: Inferred from mutant phenotype	26902285	MGI
acts upstream of or within vasculogenesis	IMP IMP: Inferred from mutant phenotype	16354681	MGI
involved in wound healing	IMP IMP: Inferred from mutant phenotype	23918388	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of TEAD-YAP complex	IPI IPI: Inferred from physical interaction	11358867	MGI
located in cell-cell junction	IDA IDA: Inferred from direct assay	29400695	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	18369314	MGI
located in cytosol	IDA IDA: Inferred from direct assay	21385842	MGI
located in female germ cell nucleus	IDA IDA: Inferred from direct assay	26902285	MGI
located in membrane	IDA IDA: Inferred from direct assay	23863479	MGI
is active in nucleus	IDA IDA: Inferred from direct assay	26902285	MGI
located in nucleus	IDA IDA: Inferred from direct assay	18369314	MGI
part of transcription regulator complex	IGI IGI: Inferred from genetic interaction	16207754	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Yap1 Protein Structure

0
100
200
300
400
488 a.a.

Protein Preferred Names

Protein Names

transcriptional coactivator YAP1

65 kDa Yes-associated protein	Yes-associated protein isoform a474
Yes-associated protein isoform a475	Yes-associated protein isoform a476
Yes-associated protein isoform b309	Yes-associated protein isoform b313
Yes-associated protein isoform b325	protein yorkie homolog
yes-associated protein YAP65 homolog	yes-associated protein, 65 kDa
yorkie homolog

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-E70293	N-Acetylgalactosaminyltransferase 12		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Yap1	NCBI	NCBI:10413

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