Erfe - erythroferrone Gene

Mus musculus

Also known as Fam132b; myonectin; 4832406C22

Gene ID: 227358 | Gene type: protein coding

About Erfe

Summary

Enables hormone activity and identical protein binding activity. Involved in cellular iron ion homeostasis. Acts upstream of or within positive regulation of fatty acid transport and regulation of fatty acid metabolic process. Located in extracellular space. Orthologous to human ERFE (erythroferrone). [provided by Alliance of Genome Resources, Apr 2022]

Erfe Products(1)

mRNA	Protein	Name
NM_173395.2	NP_775571.2	erythroferrone precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables hormone activity	IDA IDA: Inferred from direct assay	24880340	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	22351773	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	30097509	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of establishment of localization in cell	IDA IDA: Inferred from direct assay	22351773	MGI
acts upstream of fatty acid transport	IDA IDA: Inferred from direct assay	22351773	MGI
involved in intracellular iron ion homeostasis	IMP IMP: Inferred from mutant phenotype	24880340	MGI
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	30566056	MGI
involved in negative regulation of autophagy	IMP IMP: Inferred from mutant phenotype	24187137	MGI
involved in negative regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	34002695	MGI
acts upstream of negative regulation of osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	34002695	MGI
acts upstream of or within positive regulation of fatty acid transport	IDA IDA: Inferred from direct assay	22351773	MGI
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	30566056	MGI
acts upstream of or within regulation of fatty acid metabolic process	IDA IDA: Inferred from direct assay	22351773	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular region	IDA IDA: Inferred from direct assay	24880340	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	22351773	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

erythroferrone

complement C1q tumor necrosis factor-related protein 15	family with sequence similarity 132, member B
protein FAM132B

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04489	ERFE Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Erfe	NCBI	NCBI:151176
Canis familiaris	Erfe	NCBI	NCBI:102157118
Macaca fascicularis	Erfe	NCBI	NCBI:102136484
Canis lupus familiaris	Erfe	NCBI
Susscrofa domestica	Erfe	NCBI
Rattus norvegicus	Erfe	NCBI	NCBI:681056
Macaca mulatta	Erfe	NCBI	NCBI:706226

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