CLCA4 - chloride channel accessory 4 Gene

Homo sapiens

Also known as CaCC; CaCC2

Gene ID: 22802 | Gene type: protein coding

About CLCA4

Cytogenetic location: 1p22.3 Genomic coordinates (GRCh38): 1:86,547,078-86,580,754 (from NCBI)

This gene has 2 transcripts (splice variants), 130 orthologues, 2 paralogues and is associated with 1 phenotype. Biased expression in colon (RPKM 204.3), esophagus (RPKM 195.4) and 1 other tissue.

Summary

The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. Alternative splicing results in multiple transcript variants, only one of which is thought to be protein coding. [provided by RefSeq, Dec 2008]

CLCA4 Products(1)

mRNA	Protein	Name
NM_012128.4	NP_036260.2	calcium-activated chloride channel regulator 4 precursor

CLCA4 Protein Structure

CLCA

VWA_2

0
200
400
600
800
919 a.a.

Protein Preferred Names

Protein Names

calcium-activated chloride channel regulator 4

caCC-2

Related Diseases

Diseases

Alias

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Leopard Syndrome 2

LPRD2	Noonan Syndrome With Multiple Lentigines 2
Leopard Syndrome, Type 2

Colon Mucinous Adenocarcinoma

Colonic Mucinous Adenocarcinoma

Mucinous Adenocarcinoma Of The Colon

Noonan Syndrome 5

NS5	Noonan Syndrome, Type 5

Cecum Adenocarcinoma

Cecal Adenocarcinoma

Adenocarcinoma Of Cecum

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02750	CLCA4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CLCA4	VGNC	VGNC:60920
Canis familiaris	CLCA4	VGNC	VGNC:39298
Bos taurus	CLCA4	VGNC	VGNC:54909
Macaca mulatta	CLCA4	VGNC	VGNC:99868
Rattus norvegicus	CLCA4	RGD	RGD:1303234

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