RASA3 - RAS p21 protein activator 3 Gene

Homo sapiens

Also known as GAPIII; GAP1IP4BP

Gene ID: 22821 | Gene type: protein coding

About RASA3

Cytogenetic location: 13q34 Genomic coordinates (GRCh38): 13:113,977,783-114,132,623 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 216 orthologues and 10 paralogues. Ubiquitous expression in fat (RPKM 14.2), lymph node (RPKM 12.1) and 25 other tissues.

Summary

This gene encodes a protein that binds inositol 1,3,4,5-tetrakisphosphate and stimulates the GTPase activity of Ras p21. This protein functions as a negative regulator of the Ras signalling pathway. It is localized to the cell membrane via a pleckstrin homology (PH) domain in the C-terminal region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

RASA3 Products(3)

mRNA	Protein	Name
NM_001320821.2	NP_001307750.1	ras GTPase-activating protein 3 isoform 2
NM_001320822.2	NP_001307751.1	ras GTPase-activating protein 3 isoform 3
NM_007368.4	NP_031394.2	ras GTPase-activating protein 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium channel regulator activity	IDA IDA: Inferred from direct assay	10828023	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in platelet activation	IDA IDA: Inferred from direct assay	10828023	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasmic side of plasma membrane	IDA IDA: Inferred from direct assay	10828023	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RASA3 Protein Structure

RasGAP

BTK

0
200
400
600
834 a.a.

Protein Preferred Names

Protein Names

ras GTPase-activating protein 3

GTPase activating protein III

Related Diseases

Diseases

Alias

Paralytic Poliomyelitis

Poliomyelitis, Paralytic

Poliomyelitis

Polio

Infantile Paralysis

Acquired Thrombocytopenia

Secondary Thrombocytopenia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11680	RASA3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RASA3	VGNC	VGNC:64496
Macaca mulatta	RASA3	VGNC	VGNC:76513
Canis familiaris	RASA3	VGNC	VGNC:45361
Rattus norvegicus	RASA3	RGD	RGD:69365
Bos taurus	RASA3	VGNC	VGNC:33737
Mus musculus	RASA3	MGD	MGI:1197013

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