MTF2 - metal response element binding transcription factor 2 Gene

Homo sapiens

Also known as M96; PCL2; TDRD19A; dJ976O13.2

Gene ID: 22823 | Gene type: protein coding

About MTF2

Cytogenetic location: 1p22.1 Genomic coordinates (GRCh38): 1:93,079,283-93,139,076 (from NCBI)

This gene has 14 transcripts (splice variants), 208 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 5.1), lymph node (RPKM 4.5) and 25 other tissues.

Summary

Enables methylated histone binding activity and transcription corepressor binding activity. Predicted to be involved in several processes, including regulation of histone H3-K27 methylation; regulation of transcription by RNA polymerase II; and segment specification. Predicted to act upstream of or within cellular response to Leukemia Inhibitory Factor. Located in cytoplasm; focal adhesion; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

MTF2 Products(4)

mRNA	Protein	Name
NM_001164391.2	NP_001157863.1	metal-response element-binding transcription factor 2 isoform c
NM_001164392.2	NP_001157864.1	metal-response element-binding transcription factor 2 isoform b
NM_001164393.2	NP_001157865.1	metal-response element-binding transcription factor 2 isoform c
NM_007358.4	NP_031384.1	metal-response element-binding transcription factor 2 isoform a

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables methylated histone binding	IDA IDA: Inferred from direct assay	23142980	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables transcription corepressor binding	IPI IPI: Inferred from physical interaction	29628311	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	8619255	GOA
located in nucleus	IDA IDA: Inferred from direct assay	8619255	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MTF2 Protein Structure

PHD

Mtf2_C

0
100
200
300
400
500
593 a.a.

Protein Preferred Names

Protein Names

metal-response element-binding transcription factor 2

hPCl2

Related Diseases

Diseases

Alias

Non-Syndromic X-Linked Intellectual Disability 14

Mrx14

Retinitis Pigmentosa 48

RP48	Retinitis Pigmentosa, Type 48

Voyeurism

Weaver Syndrome

Wss	Weaver-Smith Syndrome
WVS	Weaver-Like Syndrome
Weaver-Williams Syndrome	Camptodactyly-Overgrowth-Unusual Facies Syndrome
Camptodactyly - Overgrowth - Unusual Facies	Ezh2 Related Overgrowth
Overgrowth Syndrome With Accelerated Skeletal Maturation, Unusual Facies, And Camptodactyly	Weaver Smith Syndrome
Weaver Like Syndrome	Weaver Williams Syndrome
Camptodactyly-Overgrowth-Unusual Facies	Weaver Syndrome 1
Weaver Syndrome 2	Wvs1
Wvs2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08766	MTF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MTF2	VGNC	VGNC:63647
Mus musculus	MTF2	MGD	MGI:105050
Rattus norvegicus	MTF2	RGD	RGD:1304727
Bos taurus	MTF2	VGNC	VGNC:31723
Macaca mulatta	MTF2	VGNC	VGNC:74858
Canis familiaris	MTF2	VGNC	VGNC:43467

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