2. Gene
  3. ENPP4 - ectonucleotide pyrophosphatase/phosphodiesterase 4 Gene

ENPP4 - ectonucleotide pyrophosphatase/phosphodiesterase 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as NPP4

Gene ID: 22875 | Gene type: protein coding

About ENPP4

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:46,129,989-46,146,688 (from NCBI)

This gene has 1 transcript (splice variant), 214 orthologues and 6 paralogues. Ubiquitous expression in bone marrow (RPKM 15.7), brain (RPKM 14.1) and 24 other tissues.

Summary

Enables bis(5'-adenosyl)-triphosphatase activity. Involved in positive regulation of blood coagulation and purine ribonucleoside catabolic process. Located in extracellular exosome and membrane. [provided by Alliance of Genome Resources, Apr 2022]

ENPP4 Products(1)

mRNA Protein Name
NM_014936.5 NP_055751.1 bis(5'-adenosyl)-triphosphatase ENPP4 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables bis(5'-adenosyl)-triphosphatase activity IDA
IDA: Inferred from direct assay
22995898 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of blood coagulation IDA
IDA: Inferred from direct assay
22995898 GOA
involved in purine ribonucleoside catabolic process IDA
IDA: Inferred from direct assay
22995898 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ENPP4 Protein Structure

Phosphodiest

Phosphodiest: Type I phosphodiesterase / nucleotide pyrophosphatase (28 - 339)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 453 a.a.
Protein Preferred Names Protein Names

bis(5'-adenosyl)-triphosphatase ENPP4

AP3A hydrolase

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04390 ENPP4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ENPP4 RGD RGD:1308689
Canis familiaris ENPP4 VGNC VGNC:49603
Macaca mulatta ENPP4 VGNC VGNC:81066
Mus musculus ENPP4 MGD MGI:2682634
Felis catus ENPP4 VGNC VGNC:102419
Bos taurus ENPP4 VGNC VGNC:49551