INPP5F - inositol polyphosphate-5-phosphatase F Gene

Homo sapiens

Also known as SAC2; hSAC2; MSTP007; MSTPO47

Gene ID: 22876 | Gene type: protein coding

About INPP5F

Cytogenetic location: 10q26.11 Genomic coordinates (GRCh38): 10:119,726,050-119,829,147 (from NCBI)

This gene has 21 transcripts (splice variants), 217 orthologues and 13 paralogues. Broad expression in brain (RPKM 17.8), testis (RPKM 4.5) and 22 other tissues.

Summary

The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase and contains a Sac domain. The activity of this protein is specific for phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]

INPP5F Products(3)

mRNA	Protein	Name
NM_001243194.2	NP_001230123.1	phosphatidylinositide phosphatase SAC2 isoform 2
NM_001243195.2	NP_001230124.1	phosphatidylinositide phosphatase SAC2 isoform 3
NM_014937.4	NP_055752.1	phosphatidylinositide phosphatase SAC2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables phosphatidylinositol phosphate 4-phosphatase activity	IDA IDA: Inferred from direct assay	25869669	GOA
NOT enables phosphatidylinositol phosphate 5-phosphatase activity	IDA IDA: Inferred from direct assay	25869669	GOA
enables phosphatidylinositol phosphate 5-phosphatase activity	IDA IDA: Inferred from direct assay	11274189	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25476455	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	25869669	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of tyrosine phosphorylation of STAT protein	IDA IDA: Inferred from direct assay	25476455	GOA
involved in phosphatidylinositol dephosphorylation	IDA IDA: Inferred from direct assay	11274189	GOA
involved in positive regulation of receptor recycling	IDA IDA: Inferred from direct assay	25869669	GOA
involved in regulation of cell motility	IMP IMP: Inferred from mutant phenotype	25869669	GOA
involved in regulation of endocytic recycling	IMP IMP: Inferred from mutant phenotype	25869669	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in clathrin-coated endocytic vesicle	IDA IDA: Inferred from direct assay	25869669	GOA
colocalizes with clathrin-coated pit	IDA IDA: Inferred from direct assay	25869669	GOA
located in early endosome	IDA IDA: Inferred from direct assay	25869669	GOA
located in recycling endosome	IDA IDA: Inferred from direct assay	25869669	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

INPP5F Protein Structure

Syja_N

hSac2

0
200
400
600
800
1000
1132 a.a.

Protein Preferred Names

Protein Names

phosphatidylinositide phosphatase SAC2

Sac domain-containing inositol phosphatase 2

Related Diseases

Diseases

Alias

Foramen Magnum Meningioma

Meningioma Of The Foramen Magnum

Parkinson Disease 21

PARK21	Parkinson'S Disease 21
Parkinson Disease, Type 21

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06831	INPP5F Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	INPP5F	MGD	MGI:2141867
Macaca mulatta	INPP5F	VGNC	VGNC:73610
Canis familiaris	INPP5F	VGNC	VGNC:42034
Bos taurus	INPP5F	VGNC	VGNC:106784
Rattus norvegicus	INPP5F	RGD	RGD:1305777
Felis catus	INPP5F	VGNC	VGNC:62930

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