DENND3 - DENN domain containing 3 Gene

Homo sapiens

Gene ID: 22898 | Gene type: protein coding

About DENND3

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:141,128,589-141,195,804 (from NCBI)

This gene has 22 transcripts (splice variants), 284 orthologues and 3 paralogues. Broad expression in bone marrow (RPKM 17.0), lung (RPKM 14.2) and 23 other tissues.

Summary

Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in cellular protein catabolic process; endosome to lysosome transport; and regulation of Rab protein signal transduction. Predicted to be located in cytosol. Predicted to be active in cytoplasmic vesicle. [provided by Alliance of Genome Resources, Apr 2022]

DENND3 Products(4)

mRNA	Protein	Name
NM_001352890.3	NP_001339819.2	DENN domain-containing protein 3 isoform 1
NM_001352891.3	NP_001339820.2	DENN domain-containing protein 3 isoform 3
NM_001362798.2	NP_001349727.1	DENN domain-containing protein 3 isoform 4
NM_014957.5	NP_055772.3	DENN domain-containing protein 3 isoform 2

DENND3 Protein Structure

uDENN

DENN

dDENN

WD40

0
200
400
600
800
1000
1198 a.a.

Protein Preferred Names

Protein Names

DENN domain-containing protein 3

DENN/MADD domain containing 3

Related Diseases

Diseases

Alias

Hirschsprung Disease 1

Hirschsprung Disease	Aganglionic Megacolon
Hscr	Hirschsprung'S Disease
Congenital Megacolon	Congenital Intestinal Aganglionosis
Colonic Aganglionosis	Hirschsprung Disease, Susceptibility To, 1
Hirschsprung Disease, Protection Against	HSCR1
Mgc	Pelvirectal Achalasia
Total Intestinal Aganglionosis	Megacolon, Aganglionic
Macrocolon	Hscr 1
Hirschsprung Disease Type 1	Hirschsprung Disease, Type 1
Congenital Dilatation Of Colon	Aganglionosis
Congenital Aganglionic Megacolon	Aganglionosis Of Colon
Bowel Aganglionosis	Colon Aganglionosis
Hirschsprung Megacolon

Sarcosinemia

Sarcosine Dehydrogenase Complex Deficiency	Sard Deficiency
Sardh Deficiency	SARCOS
Hypersarcosinemia	Sardhd
Demethylation Defect Of N-Methylglycine

Janus Kinase-3 Deficiency

Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 1

Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome	Berdon Syndrome
MMIHS	Megacystis Microcolon Intestinal Hypoperistalsis Syndrome
Megacystis, Microcolon, Hypoperistalsis Syndrome	Visceral Myopathy
Mmih Syndrome	Megacystis-Microcolon-Intestinal Hypoperistalsis-Hydronephrosis Syndrome
MMIHS1	Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome, Mmih
Mmhs

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03687	DENND3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DENND3	MGD	MGI:2146009
Felis catus	DENND3	VGNC	VGNC:61436
Rattus norvegicus	DENND3	RGD	RGD:1311559
Bos taurus	DENND3	VGNC	VGNC:27998
Canis familiaris	DENND3	VGNC	VGNC:39889
Macaca mulatta	DENND3	VGNC	VGNC:71811

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