CARD8 - caspase recruitment domain family member 8 Gene

Homo sapiens

Also known as NDPP; DACAR; DAKAR; NDPP1; TUCAN; CARDINAL

Gene ID: 22900 | Gene type: protein coding

About CARD8

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:48,179,825-48,255,946 (from NCBI)

This gene has 31 transcripts (splice variants), 96 orthologues and is associated with 1 phenotype. Broad expression in spleen (RPKM 13.6), lymph node (RPKM 11.5) and 24 other tissues.

Summary

The protein encoded by this gene belongs to the Caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and Apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]

CARD8 Products(17)

mRNA	Protein	Name
NM_001184900.3	NP_001171829.1	caspase recruitment domain-containing protein 8 isoform a
NM_001184901.1	NP_001171830.1	caspase recruitment domain-containing protein 8 isoform b
NM_001184902.2	NP_001171831.1	caspase recruitment domain-containing protein 8 isoform c
NM_001184903.1	NP_001171832.1	caspase recruitment domain-containing protein 8 isoform c
NM_001184904.2	NP_001171833.1	caspase recruitment domain-containing protein 8 isoform d
NM_001351782.2	NP_001338711.1	caspase recruitment domain-containing protein 8 isoform a
NM_001351783.2	NP_001338712.1	caspase recruitment domain-containing protein 8 isoform b
NM_001351784.2	NP_001338713.1	caspase recruitment domain-containing protein 8 isoform e
NM_001351786.2	NP_001338715.1	caspase recruitment domain-containing protein 8 isoform f
NM_001351787.2	NP_001338716.1	caspase recruitment domain-containing protein 8 isoform g
NM_001351788.2	NP_001338717.1	caspase recruitment domain-containing protein 8 isoform h
NM_001351789.2	NP_001338718.1	caspase recruitment domain-containing protein 8 isoform h
NM_001351790.2	NP_001338719.1	caspase recruitment domain-containing protein 8 isoform i
NM_001351791.2	NP_001338720.1	caspase recruitment domain-containing protein 8 isoform j
NM_001351792.2	NP_001338721.1	caspase recruitment domain-containing protein 8 isoform j
NM_001365950.1	NP_001352879.1	caspase recruitment domain-containing protein 8 isoform k
NM_014959.5	NP_055774.2	caspase recruitment domain-containing protein 8 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables CARD domain binding	IPI IPI: Inferred from physical interaction	11821383	GOA
enables NACHT domain binding	IPI IPI: Inferred from physical interaction	15030775	GOA
enables cysteine-type endopeptidase activator activity	IDA IDA: Inferred from direct assay	15030775	GOA
enables endopeptidase activity	IDA IDA: Inferred from direct assay	22087307	GOA
enables molecular condensate scaffold activity	IDA IDA: Inferred from direct assay	33053349	GOA
enables pattern recognition receptor activity	IDA IDA: Inferred from direct assay	33542150	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11551959	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	15030775	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in CARD8 inflammasome complex assembly	IDA IDA: Inferred from direct assay	31525884	GOA
involved in antiviral innate immune response	IDA IDA: Inferred from direct assay	33542150	GOA
involved in defense response to virus	IDA IDA: Inferred from direct assay	33542150	GOA
involved in inhibition of cysteine-type endopeptidase activity	IDA IDA: Inferred from direct assay	11821383	GOA
involved in negative regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	11821383	GOA
involved in negative regulation of NLRP3 inflammasome complex assembly	IDA IDA: Inferred from direct assay	24517500	GOA
involved in negative regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	11551959	GOA
involved in negative regulation of interleukin-1 beta production	IDA IDA: Inferred from direct assay	11821383	GOA
involved in negative regulation of lipopolysaccharide-mediated signaling pathway	IDA IDA: Inferred from direct assay	11821383	GOA
involved in negative regulation of tumor necrosis factor-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	11821383	GOA
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	11821383	GOA
involved in positive regulation of interleukin-1 beta production	IDA IDA: Inferred from direct assay	15030775	GOA
involved in protein homooligomerization	IDA IDA: Inferred from direct assay	33420028	GOA
involved in pyroptotic inflammatory response	IDA IDA: Inferred from direct assay	32840892	GOA
involved in self proteolysis	IDA IDA: Inferred from direct assay	33542150	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of CARD8 inflammasome complex	IDA IDA: Inferred from direct assay	15030775	GOA
part of NLRP3 inflammasome complex	IDA IDA: Inferred from direct assay	15030775	GOA
part of canonical inflammasome complex	IDA IDA: Inferred from direct assay	34019797	GOA
is active in cytoplasm	IDA IDA: Inferred from direct assay	24517500	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	15030775	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11551959	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	11821383	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CARD8 Protein Structure

FIIND

CARD

0
100
200
300
400
500
537 a.a.

Protein Preferred Names

Protein Names

caspase recruitment domain-containing protein 8

CARD inhibitor of NF-kappaB-activating ligands

Related Diseases

Diseases

Alias

Inflammatory Bowel Disease 30

IBD30

Pharyngitis

Acute Pharyngitis	Chronic Pharyngitis
Acute Sore Throat	Chronic Sore Throat
Persistent Sore Throat	Pharyngeal Diseases
Chronic Pharyn/Nasopharyngitis	Chronic Pharyngitis And Nasopharyngitis
Inflamed Throat	Pharyngeal Disease
Pharyngeal Disorder	Pharyngitis - Acute
Sore Throat - Chronic	Acute Pharyngitis Nos
Acute Sore Throat Nos	Acute Throat Inflammation
Infective Pharyngitis	Infection Of Pharynx
Acute Infective Pharyngitis	Acute Infective Pharyngitis Nos
Acute Pharyngeal Inflammation	Inflammation Of The Throat
Throat Inflammation	Throat Infection
Putrid Pharyngitis	Pharyngeal Inflammation
Pharyngitis Nos	Chronic Throat Pain
Throat Catarrh

Arteriosclerosis Obliterans

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Cervical Adenitis

Cervical Lymphadenitis

Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint

Anthracosis

Black Lung	Coal Workers' Pneumoconiosis
Melanoedema	Black Lung Disease
Pneumoconiosis	Coal Miner'S Pneumoconiosis
Coal Workers' Lung	Coal Worker'S Pneumoconiosis
Coal Workers Pneumoconiosis	Coal Miners' Lung
Coal Miners' Pneumoconiosis	Coal Pneumoconiosis
Colliers' Anthracosis	Colliers' Lung
Lung Melanosis	Miners' Asthma
Miners' Lung	Pneumomelanosis
Cwp - [Coalworkers Pneumoconiosis]	Fibrosis Of Lung With Anthracosilicosis
Lung Fibrosis With Anthracosis	Miners' Pneumoconiosis
Carbon Lung	Coalworker Lung
Collier'S Asthma	Anthracosilicosis
Lung Anthracosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01922	CARD8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CARD8	VGNC	VGNC:60368
Rattus norvegicus	CARD8	RGD	RGD:1593294

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