MAST1 - microtubule associated serine/threonine kinase 1 Gene

Homo sapiens

Also known as SAST; MCCCHCM

Gene ID: 22983 | Gene type: protein coding

About MAST1

Cytogenetic location: 19p13.13 Genomic coordinates (GRCh38): 19:12,838,515-12,874,952 (from NCBI)

This gene has 9 transcripts (splice variants), 299 orthologues, 13 paralogues and is associated with 2 phenotypes. Biased expression in brain (RPKM 10.3), testis (RPKM 1.3) and 1 other tissue.

Summary

This gene is a member of the microtubule-associated serine/threonine kinase (MAST) family. The protein encoded by this gene has an N-terminal serine/threonine kinase domain followed by a postsynaptic density protein-95/discs large/zona occludens-1 (PDZ) domain. In mouse and rat, the orthologous protein associates with the Cytoskeleton and can bind both beta-2-syntrophin and neuronal nitric oxide synthase (nNOS) through its PDZ domain. In mouse and rat, this protein also co-localizes with dystrophin- and utrophin-associated protein complexes (DAPC/UAPC) in the vascular endothelium of the central nervous system. [provided by RefSeq, May 2017]

MAST1 Products(1)

mRNA	Protein	Name
NM_014975.3	NP_055790.1	microtubule-associated serine/threonine-protein kinase 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20029029	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in brain development	IMP IMP: Inferred from mutant phenotype	30449657	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAST1 Protein Structure

DUF1908

Pkinase

PDZ

0
300
600
900
1200
1570 a.a.

Protein Preferred Names

Protein Names

microtubule-associated serine/threonine-protein kinase 1

syntrophin associated serine/threonine kinase

MAST1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MAST1	Q9Y2H9	EGFR	Homo sapiens	P00533	Ub Reconstruction	20029029

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Mega-Corpus-Callosum Syndrome With Cerebellar Hypoplasia And Cortical Malformations

MCCCHCM

Cerebellar Hypoplasia

Megalencephaly

Macroencephaly

Macrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08161	MAST1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MAST1	MGD	MGI:1861901
Rattus norvegicus	MAST1	RGD	RGD:631372
Bos taurus	MAST1	VGNC	VGNC:31257
Macaca mulatta	MAST1	VGNC	VGNC:82182
Felis catus	MAST1	VGNC	VGNC:63393
Canis familiaris	MAST1	VGNC	VGNC:43032

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