ABCF1 - ATP binding cassette subfamily F member 1 Gene

Homo sapiens

Also known as ABC27; ABC50

Gene ID: 23 | Gene type: protein coding

About ABCF1

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:30,571,442-30,591,522 (from NCBI)

This gene has 7 transcripts (splice variants), 1 gene allele, 196 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 25.4), bone marrow (RPKM 18.2) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the GCN20 subfamily. Unlike Other members of the superfamily, this protein lacks the transmembrane domains which are characteristic of most ABC transporters. This protein may be regulated by tumor necrosis factor-alpha and play a role in enhancement of protein synthesis and the inflammation process. [provided by RefSeq, Jul 2008]

ABCF1 Products(2)

mRNA	Protein	Name
NM_001025091.2	NP_001020262.1	ATP-binding cassette sub-family F member 1 isoform a
NM_001090.3	NP_001081.1	ATP-binding cassette sub-family F member 1 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	19570978	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17894550	GOA
enables ribosome binding	IDA IDA: Inferred from direct assay	17894550	GOA
enables translation activator activity	IDA IDA: Inferred from direct assay	19570978	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of translation	IDA IDA: Inferred from direct assay	19570978	GOA
NOT involved in ribosome biogenesis	IDA IDA: Inferred from direct assay	19570978	GOA
involved in translational initiation	IMP IMP: Inferred from mutant phenotype	19570978	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	19570978	GOA
located in nuclear envelope	IDA IDA: Inferred from direct assay	19570978	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	19570978	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ABCF1 Protein Structure

ABC_tran

ABC_tran_Xtn

ABC_tran

0
200
400
600
845 a.a.

Protein Preferred Names

Protein Names

ATP-binding cassette sub-family F member 1

ATP-binding cassette 50 (TNF-alpha stimulated)

ABCF1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82967	ABCF1 Antibody (YA2712)	WB, IHC-P, ICC/IF	Human, Rat

Related Diseases

Diseases

Alias

Bile Acid Synthesis Defect, Congenital, 5

Congenital Bile Acid Synthesis Defect 5	CBAS5
Bile Acid Synthesis Defect, Congenital, Type 5

Neurofibromatosis-Noonan Syndrome

NFNS	Neurofibromatosis Type 1
Neurofibromatosis With Noonan Phenotype	Nf1
Von Recklinghausen Disease	Neurofibromatosis Type 1-Noonan Syndrome
Noonan Neurofibromatosis Syndrome	Recklinghausen'S Disease
Noonan-Neurofibromatosis Syndrome	Fibromatosis Multiple Non Ossifying
Disseminated Nonossifying Fibromas In Association With Cafe-Au-Lait Spots	Jaffe Campanacci Syndrome
Type 1 Neurofibromatosis	Neurofibromatosis 1
Peripheral Neurofibromatosis	Recklinghausen Disease, Nerve
Jaffe-Campanacci Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00073	ABCF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ABCF1	VGNC	VGNC:69582
Mus musculus	ABCF1	MGD	MGI:1351658
Canis familiaris	ABCF1	VGNC	VGNC:37450
Felis catus	ABCF1	VGNC	VGNC:68232
Rattus norvegicus	ABCF1	RGD	RGD:620286
Bos taurus	ABCF1	VGNC	VGNC:25480

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