FOXL1 - forkhead box L1 Gene

Homo sapiens

Also known as FKH6; FKHL11; FREAC7

Gene ID: 2300 | Gene type: protein coding

About FOXL1

Cytogenetic location: 16q24.1 Genomic coordinates (GRCh38): 16:86,578,549-86,583,478 (from NCBI)

This gene has 2 transcripts (splice variants), 169 orthologues and 42 paralogues.

Summary

This gene encodes a member of the forkhead/winged helix-box (FOX) family of transcription factors. FOX transcription factors are characterized by a distinct DNA-binding forkhead domain and play critical roles in the regulation of multiple processes including metabolism, cell proliferation and gene expression during ontogenesis. [provided by RefSeq, Nov 2012]

FOXL1 Products(1)

mRNA	Protein	Name
NM_005250.3	NP_005241.1	forkhead box protein L1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	7957066	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	7957066	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in heart development	IMP IMP: Inferred from mutant phenotype	21457232	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	34633540	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FOXL1 Protein Structure

Forkhead

0
100
200
300
345 a.a.

Protein Preferred Names

Protein Names

forkhead box protein L1

forkhead-like 11

Related Diseases

Diseases

Alias

Lymphedema-Distichiasis Syndrome

Lymphedema With Distichiasis	Lymphedema-Distichiasis Syndrome With Renal Disease And Diabetes Mellitus
LPHDST	Distichiasis-Lymphedema Syndrome
Lymphedema Distichiasis Syndrome	Hereditary Lymphedema-Distichiasis Syndrome
Lymphedema Distichiasis

Hypoplastic Left Heart Syndrome

Hlhs	Heart, Hypoplastic Left, Syndrome
Hypoplasia Of The Left Heart	Left Heart Hypoplasia Syndrome
Hlhs - [Hypoplastic Left Heart Syndrome]	Hypoplasia Of Aortic Valve, In Hypoplastic Left Heart Syndrome
Atresia Of Mitral Valve, In Hypoplastic Left Heart Syndrome	Atresia Or Marked Hypoplasia Of Aortic Orifice Or Valve, With Hypoplasia Of Ascending Aorta And Defective Development Of Left Ventricle
Atresia Or Marked Hypoplasia, Of Aortic Orifice Or Valve, With Hypoplasia Of Ascending Aorta And Defective Development Of Left Ventricle With Mitral Valve Atresia	Aortic Valve Atresia, In Hypoplastic Left Heart Syndrome
Ascending Aorta Hypoplasia, In Hypoplastic Left Heart Syndrome

Otosclerosis

Otospongiosis

Vacterl Association

Vater Association

Vater Syndrome

Pancreas, Annular

Annular Pancreas	Pancreas Annulare
Congenital Annular Pancreas

Microphthalmia, Syndromic 3

MCOPS3	Aeg Syndrome
Microphthalmia And Esophageal Atresia Syndrome	Anophthalmia/Microphthalmia-Esophageal Atresia Syndrome
Anophthalmia-Esophageal-Genital Syndrome	Optic Nerve Hypoplasia And Abnormalities Of The Central Nervous System
Syndromic Microphthalmia 3	Sox2 Anophthalmia Syndrome
Anophthalmia Clinical With Associated Anomalies	Anophthalmia Esophageal Genital Syndrome
Anophthalmia Microphthalmia Esophageal Atresia	Syndromic Microphthalmia Type 3
Sox2-Related Eye Disorders	Anophthalmia, Clinical, With Associated Anomalies
Syndromic Microphthalmia, Type 3	Microphthalmia, Syndromic, 3
Anophthalmia/Microphthalmia-Esophageal Atresia	Microphthalmia Syndromic, Type 3

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05061	FOXL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	FOXL1	VGNC	VGNC:40958
Rattus norvegicus	FOXL1	RGD	RGD:1584212
Bos taurus	FOXL1	VGNC	VGNC:29092
Mus musculus	FOXL1	MGD	MGI:1347469

Name
Email *

	Sorry, but the email address you supplied was invalid.