Shb - src homology 2 domain-containing transforming protein B Gene

Mus musculus

Gene ID: 230126 | Gene type: protein coding

About Shb

Summary

Predicted to enable phosphotyrosine residue binding activity. Acts upstream of or within several processes, including hematopoietic stem cell proliferation; negative regulation of oocyte maturation; and positive regulation of immune response. Predicted to be located in cytoplasmic ribonucleoprotein granule; cytosol; and nucleoplasm. Is expressed in brain; molar; and sensory organ. Orthologous to human SHB (SH2 domain containing adaptor protein B). [provided by Alliance of Genome Resources, Apr 2022]

Shb Products(1)

mRNA	Protein	Name
NM_001033306.1	NP_001028478.1	SH2 domain-containing adapter protein B

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables signaling receptor complex adaptor activity	IDA IDA: Inferred from direct assay	8302579	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within B cell proliferation	IDA IDA: Inferred from direct assay	11786382	MGI
acts upstream of or within T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	24645804	MGI
acts upstream of or within blood vessel development	IMP IMP: Inferred from mutant phenotype	19223532	MGI
acts upstream of or within blood vessel morphogenesis	IGI IGI: Inferred from genetic interaction	15919073	MGI
acts upstream of or within blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	15919073	MGI
acts upstream of or within hematopoietic stem cell proliferation	IMP IMP: Inferred from mutant phenotype	23528453	MGI
acts upstream of or within hemopoiesis	IMP IMP: Inferred from mutant phenotype	16971391	MGI
acts upstream of or within negative regulation of oocyte maturation	IMP IMP: Inferred from mutant phenotype	20585392	MGI
acts upstream of or within negative regulation of protein kinase activity	IMP IMP: Inferred from mutant phenotype	23528453	MGI
acts upstream of or within positive regulation of T-helper cell differentiation	IMP IMP: Inferred from mutant phenotype	24645804	MGI
acts upstream of or within positive regulation of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	23528453	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

SH2 domain-containing adapter protein B

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0110	Gestodene	Agonist	99.90%	Unkown
HY-B0110R	Gestodene (Standard)	Agonist	/	Unkown

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19360	Sulprostone	Agonist	≥99.0%	Unkown
HY-B0110S	Gestodene-d6	Agonist	/	Unkown
HY-P5165	Maurotoxin	Inhibitor	/	Unkown
HY-RS12854	SHB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Shb	NCBI	NCBI:6461
Macaca fascicularis	Shb	NCBI	NCBI:102135347

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