MYO16 - myosin XVI Gene

Homo sapiens

Also known as MYR8; MYAP3; NYAP3; Myo16b; PPP1R107

Gene ID: 23026 | Gene type: protein coding

About MYO16

Cytogenetic location: 13q33.3 Genomic coordinates (GRCh38): 13:108,495,716-109,208,005 (from NCBI)

This gene has 6 transcripts (splice variants), 191 orthologues and 43 paralogues. Biased expression in brain (RPKM 1.6), fat (RPKM 1.1) and 8 other tissues.

Summary

This gene encodes an unconventional Myosin protein. The encoded protein has been proposed to act as a serine/threonine phosphatase-1 targeting or regulatory subunit. Studies in a rat cell line suggest that this protein may regulate cell cycle progression. A variant within this gene may be associated with susceptibility to schizophrenia and elevated expression of this gene has been observed in the frontal cortex of human schizophrenia patients. [provided by RefSeq, Mar 2017]

MYO16 Products(2)

mRNA	Protein	Name
NM_001198950.3	NP_001185879.1	unconventional myosin-XVI isoform 1
NM_015011.3	NP_055826.1	unconventional myosin-XVI isoform 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25902260	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleoplasm	IDA IDA: Inferred from direct assay	17029291	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	17029291	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MYO16 Protein Structure

Ank_2

Myosin_head

NYAP_N

0
300
600
900
1200
1500
1858 a.a.

Protein Preferred Names

Protein Names

unconventional myosin-XVI

MYO16 variant protein

Related Diseases

Diseases

Alias

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08933	MYO16 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MYO16	VGNC	VGNC:75042
Mus musculus	MYO16	MGD	MGI:2685951
Bos taurus	MYO16	VGNC	VGNC:53825
Canis familiaris	MYO16	VGNC	VGNC:43556
Rattus norvegicus	MYO16	RGD	RGD:621561
Felis catus	MYO16	VGNC	VGNC:102258

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