KIF21B - kinesin family member 21B Gene

Homo sapiens

Gene ID: 23046 | Gene type: protein coding

About KIF21B

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:200,969,390-201,023,714 (from NCBI)

This gene has 5 transcripts (splice variants), 210 orthologues and 41 paralogues. Biased expression in bone marrow (RPKM 12.6), brain (RPKM 10.5) and 11 other tissues.

Summary

This gene encodes a member of the Kinesin superfamily. Kinesins are ATP-dependent microtubule-based motor proteins that are involved in the intracellular transport of membranous organelles. Single nucleotide polymorphisms in this gene are associated with inflammatory bowel disease and multiple sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

KIF21B Products(4)

mRNA	Protein	Name
NM_001252100.2	NP_001239029.1	kinesin-like protein KIF21B isoform 1
NM_001252102.2	NP_001239031.1	kinesin-like protein KIF21B isoform 3
NM_001252103.2	NP_001239032.1	kinesin-like protein KIF21B isoform 4
NM_017596.4	NP_060066.2	kinesin-like protein KIF21B isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KIF21B Protein Structure

Kinesin

WD40

0
300
600
900
1200
1500
1637 a.a.

Protein Preferred Names

Protein Names

kinesin-like protein KIF21B

Related Diseases

Diseases

Alias

Third Cranial Nerve Disease

Disorder Of Oculomotor Nerve	Oculomotor Nerve Disorder
Oculomotor Nerve Paralysis	Third Cranial Nerve Disorder

Multiple Sclerosis

MS	Multiple Sclerosis, Susceptibility To
Disseminated Sclerosis	Multiple Sclerosis, Disease Progression, Modifier Of
Insular Sclerosis	Multiple Sclerosis Modifier Of Disease Progression
Multiple Sclerosis, Susceptibility To 1	Multiple Sclerosis, Susceptibility To, 1
Multiple Sclerosis 1	Generalized Multiple Sclerosis
Multiple Sclerosis Variant	Multiple Sclerosis Susceptibility To
Cerebrospinal Sclerosis	Generalised Multiple Sclerosis
Ms - [Multiple Sclerosis]	Disseminated Cerebrospinal Sclerosis
Disseminated Multiple Sclerosis	Disseminated Nervous System Myelosclerosis
Multiple Cerebrospinal Sclerosis	Multiple Combined Sclerosis
Multiple Sclerosis Generalised	Disseminated Brain Sclerosis
Disseminated Spinal Sclerosis	Insular Brain Sclerosis
Miliary Brain Sclerosis	Multiple Combined Sclerosis Of Spinal Cord
Multiple Ascending Sclerosis	Multiple Brain Sclerosis
Multiple Sclerosis Of Brain Stem	Multiple Sclerosis Of The Brain Stem
Multiple Sclerosis Of Cord	Sclérose En Plaques
Plaque Sclerosis	Multiple Sclerosis Of The Spinal Cord

Congenital Fibrosis Of The Extraocular Muscles

Congenital Fibrosis Of Extraocular Muscles	Cfeom
Feom	Congenital External Ophthalmoplegia
Congenital Fibrosis Syndrome	General Fibrosis Syndrome

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07275	KIF21B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	KIF21B	MGD	MGI:109234
Felis catus	KIF21B	VGNC	VGNC:63113
Rattus norvegicus	KIF21B	RGD	RGD:1306206
Macaca mulatta	KIF21B	VGNC	VGNC:73945
Bos taurus	KIF21B	VGNC	VGNC:59343
Canis familiaris	KIF21B	VGNC	VGNC:42397

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