ZSWIM8 - zinc finger SWIM-type containing 8 Gene

Homo sapiens

Also known as KIAA0913

Gene ID: 23053 | Gene type: protein coding

About ZSWIM8

Cytogenetic location: 10q22.2 Genomic coordinates (GRCh38): 10:73,785,606-73,801,793 (from NCBI)

This gene has 23 transcripts (splice variants), 210 orthologues and 3 paralogues. Ubiquitous expression in testis (RPKM 21.6), spleen (RPKM 16.0) and 25 other tissues.

Summary

Enables ubiquitin ligase-substrate adaptor activity. Involved in positive regulation of miRNA catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Part of Cul3-RING ubiquitin Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

ZSWIM8 Products(4)

mRNA	Protein	Name
NM_001242487.2	NP_001229416.1	zinc finger SWIM domain-containing protein 8 isoform 2
NM_001242488.2	NP_001229417.1	zinc finger SWIM domain-containing protein 8 isoform 3
NM_001367799.1	NP_001354728.1	zinc finger SWIM domain-containing protein 8 isoform 4
NM_015037.4	NP_055852.2	zinc finger SWIM domain-containing protein 8 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ubiquitin-like ligase-substrate adaptor activity	IDA IDA: Inferred from direct assay	33184234	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of miRNA catabolic process	IDA IDA: Inferred from direct assay	33184234	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	33184234	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	33184234	GOA
involved in target-directed miRNA degradation	IMP IMP: Inferred from mutant phenotype	33184237	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Cul3-RING ubiquitin ligase complex	IDA IDA: Inferred from direct assay	33184234	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

zinc finger SWIM domain-containing protein 8

Related Diseases

Diseases

Alias

Acromelic Frontonasal Dysostosis

AFND	Acromelic Frontonasal Dysplasia
Frontonasal Dysplasia Acromelic	Toriello Syndrome
Dysostosis, Acromelic Frontonasal	Sweet Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16206	ZSWIM8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ZSWIM8	VGNC	VGNC:37388
Canis familiaris	ZSWIM8	VGNC	VGNC:48861
Felis catus	ZSWIM8	VGNC	VGNC:67387
Macaca mulatta	ZSWIM8	VGNC	VGNC:79396
Rattus norvegicus	ZSWIM8	RGD	RGD:1309414
Mus musculus	ZSWIM8	MGD	MGI:1919156

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