SWAP70 - switching B cell complex subunit SWAP70 Gene

Homo sapiens

Also known as HSPC321; SWAP-70

Gene ID: 23075 | Gene type: protein coding

About SWAP70

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:9,664,077-9,752,993 (from NCBI)

This gene has 7 transcripts (splice variants), 282 orthologues and 2 paralogues. Ubiquitous expression in lymph node (RPKM 33.7), spleen (RPKM 30.6) and 24 other tissues.

Summary

Enables cadherin binding activity. Predicted to be involved in regulation of actin polymerization or depolymerization. Predicted to act upstream of or within isotype switching. Located in actin cytoskeleton; cytoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SWAP70 Products(2)

mRNA	Protein	Name
NM_001297714.2	NP_001284643.1	switch-associated protein 70 isoform 2
NM_015055.4	NP_055870.2	switch-associated protein 70 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24722188	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	25468996	GOA
is active in postsynapse	IDA IDA: Inferred from direct assay	30123108	GOA
is active in postsynapse	IMP IMP: Inferred from mutant phenotype	30123108	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SWAP70 Protein Structure

0
100
200
300
400
500
585 a.a.

Protein Preferred Names

Protein Names

switch-associated protein 70

SWAP switching B-cell complex 70kDa subunit

SWAP70 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SWAP70	Q9UH65	ZBTB5	Homo sapiens	O15062	Y2H Prey Pooling	25416956
Intra	SWAP70	Q9UH65	ZBTB5	Homo sapiens	O15062	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

SWAP70 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81328	Switch Associated Protein 70 Antibody (YA1073)	WB, IP	Human, Mouse, Rat, Monkey

Related Diseases

Diseases

Alias

Aleutian Mink Disease

Aleutian Disease

B-Cell Lymphoma

Lymphoma, B-Cell	B-Cell Lymphomas
B-Cell Lymphocytic Neoplasm	Lymphoma B-Cell
B-Cell Lymphoma Nos

Common Variable Immunodeficiency

Cvid	Common Variable Agammaglobulinemia
Common Variable Immune Deficiency	Acquired Hypogammaglobulinemia
Hypogamma-Globulinemia, Acquired	Idiopathic Immunoglobulin Deficiency
Primary Antibody Deficiency	Primary Hypogammaglobulinemia
Acquired Agammaglobulinemia	Sporadic Hypogammaglobulinemia
Common Variable Hypogamma-Globulinemia	Immunoglobulin Deficiency, Late-Onset
Common Variable Hypogammaglobulinemia	Immunodeficiency, Common Variable

Lymphoma, Hodgkin, Classic

Hodgkin Lymphoma	Hodgkin Disease
Hodgkin'S Lymphoma	Hodgkins Lymphoma
Classic Hodgkin Lymphoma	CHL
Hodgkin Lymphoma, Susceptibility To	Hl
Hodgkin'S Sarcoma	Stage I Subdiaphragmatic Hodgkin Lymphoma
Stage Ii Subdiaphragmatic Hodgkin Lymphoma	Lymphoma, Hodgkin'S
Classic Hodgkin Disease	Hodgkin'S Disease
Lymphoma, Hodgkin, Susceptibility To	Hodgkin'S Disease Of Intrapelvic Lymph Nodes
Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb	Malignant Lymphogranuloma
Malignant Lymphogranulomatosis	Malignant Hodgkin Lymphoma
Classical Hodgkin Lymphoma, Type Not Specified

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14063	SWAP70 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SWAP70	VGNC	VGNC:78142
Felis catus	SWAP70	VGNC	VGNC:65867
Bos taurus	SWAP70	VGNC	VGNC:54893
Canis familiaris	SWAP70	VGNC	VGNC:47009
Rattus norvegicus	SWAP70	RGD	RGD:1305579
Mus musculus	SWAP70	MGD	MGI:1298390

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