Hcrtr1 - hypocretin (orexin) receptor 1 Gene

Mus musculus

Also known as Ox1r; ox1-R; ox-1-R

Gene ID: 230777 | Gene type: protein coding

About Hcrtr1

Chromosome 4: 130,024,010-130,033,152 reverse strand.GRCm39:CM000997.3

This gene has 4 transcripts (splice variants), 94 orthologues, 16 paralogues and is associated with 4 phenotypes. Biased expression in bladder adult (RPKM 6.3), stomach adult (RPKM 2.7) and 12 other tissues.

Summary

Predicted to enable orexin receptor activity and peptide hormone binding activity. Acts upstream of or within positive regulation of ERK1 and ERK2 cascade. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including brain; genitourinary system; gut; immune system; and liver and biliary system. Orthologous to human HCRTR1 (hypocretin receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Hcrtr1 Products(4)

mRNA	Protein	Name
NM_001305392.1	NP_001292321.1	orexin/Hypocretin receptor type 1 isoform 2
NM_001163027.1	NP_001156499.1	orexin/Hypocretin receptor type 1 isoform 1
NM_001357258.1	NP_001344187.1	orexin/Hypocretin receptor type 1 isoform 2
NM_198959.2	NP_945197.2	orexin/Hypocretin receptor type 1 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22028875	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	22028875	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hcrtr1 Protein Structure

7tmA_OXR

0
100
200
300
416 a.a.

Protein Preferred Names

Protein Names

orexin/Hypocretin receptor type 1

orexin receptor type 1

hypocretin receptor type 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06051	HCRTR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06052	Hcrtr1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06053	Hcrtr1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hcrtr1	NCBI	NCBI:3061

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