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  3. PPRC1 - PPARG related coactivator 1 Gene

PPRC1 - PPARG related coactivator 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PRC

Gene ID: 23082 | Gene type: protein coding

About PPRC1

Cytogenetic location: 10q24.32 Genomic coordinates (GRCh38): 10:102,119,889-102,150,333 (from NCBI)

This gene has 6 transcripts (splice variants), 257 orthologues and 2 paralogues. Ubiquitous expression in gall bladder (RPKM 7.9), appendix (RPKM 7.5) and 25 other tissues.

Summary

The protein encoded by this gene is similar to PPAR-gamma coactivator 1 (PPARGC1/PGC-1), a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 (NRF1). This protein has been shown to interact with NRF1. It is thought to be a functional relative of PPAR-gamma coactivator 1 that activates mitochondrial biogenesis through NRF1 in response to proliferative signals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

PPRC1 Products(3)

mRNA Protein Name
NM_001288727.2 NP_001275656.1 peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform 2
NM_001288728.2 NP_001275657.1 peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform 3
NM_015062.5 NP_055877.3 peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform 1

PPRC1 Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (1545 - 1604)

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  • 1664 a.a.
Protein Preferred Names Protein Names

peroxisome proliferator-activated receptor gamma coactivator-related protein 1

PGC-1-related coactivator

Related Diseases

Diseases Alias
Epithelial Recurrent Erosion Dystrophy

ERED

Corneal Erosions, Recurring Hereditary

Col17a1

Dystrophia Helsinglandica

Dystrophia Smolandiensis

Recurrent Hereditary Corneal Erosions

Rces

Recurrent Corneal Erosion Syndrome

Recurrent Erosion Of Cornea
Oncocytoma

Oxyphilic Adenoma

Follicular Adenoma, Oxyphilic Cell

Adenoma, Oxyphilic

Hurthle Cell Tumor

Oncocytic Neoplasm
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11037 PPRC1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PPRC1 VGNC VGNC:33276
Macaca mulatta PPRC1 VGNC VGNC:76343
Felis catus PPRC1 VGNC VGNC:64335
Mus musculus PPRC1 MGD MGI:2385096
Canis familiaris PPRC1 VGNC VGNC:44928
Rattus norvegicus PPRC1 RGD RGD:1309688