Nppa - natriuretic peptide type A Gene

Mus musculus

Also known as ANP; Anf; CDD; Pnd

Gene ID: 230899 | Gene type: protein coding

About Nppa

Summary

This gene encodes members of the natriuretic family of peptides that play an important role in the control of extracellular fluid volume and electrolyte homeostasis. The encoded protein precursor undergoes proteolytic processing to generate multiple functional peptides. Mice lacking the encoded peptides exhibit salt-sensitive hypertension. The transgenic overexpression of the encoded peptides in mice decreases arterial blood pressure without inducing diuresis and natriuresis. This gene is located adjacent to another member of the natriuretic family of peptides on chromosome 4. [provided by RefSeq, Oct 2015]

Nppa Products(1)

mRNA	Protein	Name
NM_008725.3	NP_032751.1	natriuretic peptides A preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	33245046	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cardiac muscle hypertrophy in response to stress	IDA IDA: Inferred from direct assay	24137001	MGI
acts upstream of cardiac muscle hypertrophy in response to stress	IMP IMP: Inferred from mutant phenotype	26536903	MGI
acts upstream of or within cardiac muscle hypertrophy in response to stress	IMP IMP: Inferred from mutant phenotype	14985074	MGI
involved in female pregnancy	IMP IMP: Inferred from mutant phenotype	22437503	MGI
acts upstream of or within negative regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	23542788	MGI
involved in negative regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	23981445	MGI
involved in regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	22437503	MGI
acts upstream of or within sodium ion export across plasma membrane	IMP IMP: Inferred from mutant phenotype	23542788	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12738802	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	15452027	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

natriuretic peptides A

atrial natriuretic factor prohormone	atrial natriuretic peptide prohormone
atriopeptigen	cardiodilatin
natriuretic peptide precursor type A	preproANF
preproANP	preproCDD-ANF
prepronatriodilatin	proANF
proANP

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect Pre-designed Sets	Purity	Rare Diseases Unkown
HY-RS09494	NPPA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19624	Nppa Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nppa	NCBI	NCBI:4878
Canis familiaris	Nppa	NCBI	NCBI:608289
Macaca fascicularis	Nppa	NCBI	NCBI:102116318

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