RAP1GAP2 - RAP1 GTPase activating protein 2 Gene

Homo sapiens

Also known as GARNL4; RAP1GA3

Gene ID: 23108 | Gene type: protein coding

About RAP1GAP2

Cytogenetic location: 17p13.3 Genomic coordinates (GRCh38): 17:2,755,645-3,037,741 (from NCBI)

This gene has 11 transcripts (splice variants), 314 orthologues and 6 paralogues. Ubiquitous expression in brain (RPKM 11.5), bone marrow (RPKM 10.7) and 24 other tissues.

Summary

This gene encodes a GTPase-activating protein that activates the small guanine-nucleotide-binding protein Rap1 in platelets. The protein interacts with synaptotagmin-like protein 1 and Rab27 and regulates secretion of dense granules from platelets at sites of endothelial damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

RAP1GAP2 Products(5)

mRNA	Protein	Name
NM_001100398.2	NP_001093868.1	rap1 GTPase-activating protein 2 isoform 2
NM_001330058.2	NP_001316987.1	rap1 GTPase-activating protein 2 isoform 3
NM_001411048.1	NP_001397977.1	rap1 GTPase-activating protein 2 isoform 4
NM_001411049.1	NP_001397978.1	rap1 GTPase-activating protein 2 isoform 5
NM_015085.5	NP_055900.4	rap1 GTPase-activating protein 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase activator activity	EXP EXP: Inferred from Experiment	16076873	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24284068	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of cell size	IGI IGI: Inferred from genetic interaction	24284068	GOA
involved in regulation of cell size	IMP IMP: Inferred from mutant phenotype	24284068	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in centrosome	IDA IDA: Inferred from direct assay	21399614	GOA
located in plasma membrane	IGI IGI: Inferred from genetic interaction	24284068	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAP1GAP2 Protein Structure

Rap_GAP

0
200
400
600
730 a.a.

Protein Preferred Names

Protein Names

rap1 GTPase-activating protein 2

GTPase activating RANGAP domain-like 4

RAP1GAP2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RAP1GAP2	Q684P5	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	RAP1GAP2	Q684P5	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	RAP1GAP2	Q684P5	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11655	RAP1GAP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	RAP1GAP2	VGNC	VGNC:45342
Bos taurus	RAP1GAP2	VGNC	VGNC:33717
Macaca mulatta	RAP1GAP2	VGNC	VGNC:76561
Felis catus	RAP1GAP2	VGNC	VGNC:64490
Rattus norvegicus	RAP1GAP2	RGD	RGD:1304590
Mus musculus	RAP1GAP2	MGD	MGI:3028623

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