2. Gene
  3. RAP1GAP2 - RAP1 GTPase activating protein 2 Gene

RAP1GAP2 - RAP1 GTPase activating protein 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as GARNL4; RAP1GA3

Gene ID: 23108 | Gene type: protein coding

About RAP1GAP2

Cytogenetic location: 17p13.3 Genomic coordinates (GRCh38): 17:2,755,645-3,037,741 (from NCBI)

This gene has 11 transcripts (splice variants), 314 orthologues and 6 paralogues. Ubiquitous expression in brain (RPKM 11.5), bone marrow (RPKM 10.7) and 24 other tissues.

Summary

This gene encodes a GTPase-activating protein that activates the small guanine-nucleotide-binding protein Rap1 in platelets. The protein interacts with synaptotagmin-like protein 1 and Rab27 and regulates secretion of dense granules from platelets at sites of endothelial damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

RAP1GAP2 Products(5)

mRNA Protein Name
NM_001100398.2 NP_001093868.1 rap1 GTPase-activating protein 2 isoform 2
NM_001330058.2 NP_001316987.1 rap1 GTPase-activating protein 2 isoform 3
NM_001411048.1 NP_001397977.1 rap1 GTPase-activating protein 2 isoform 4
NM_001411049.1 NP_001397978.1 rap1 GTPase-activating protein 2 isoform 5
NM_015085.5 NP_055900.4 rap1 GTPase-activating protein 2 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables GTPase activator activity EXP
EXP: Inferred from Experiment
16076873 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
24284068 GOA
Biological Process GO Annotation Evidence Reference Source
involved in regulation of cell size IGI
IGI: Inferred from genetic interaction
24284068 GOA
involved in regulation of cell size IMP
IMP: Inferred from mutant phenotype
24284068 GOA
Cellular Component GO Annotation Evidence Reference Source
located in centrosome IDA
IDA: Inferred from direct assay
21399614 GOA
located in plasma membrane IGI
IGI: Inferred from genetic interaction
24284068 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAP1GAP2 Protein Structure

Rap_GAP

Rap_GAP: Rap/ran-GAP (278 - 464)

  • 0
  • 200
  • 400
  • 600
  • 730 a.a.
Protein Preferred Names Protein Names

rap1 GTPase-activating protein 2

GTPase activating RANGAP domain-like 4

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11655 RAP1GAP2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris RAP1GAP2 VGNC VGNC:45342
Bos taurus RAP1GAP2 VGNC VGNC:33717
Macaca mulatta RAP1GAP2 VGNC VGNC:76561
Felis catus RAP1GAP2 VGNC VGNC:64490
Rattus norvegicus RAP1GAP2 RGD RGD:1304590
Mus musculus RAP1GAP2 MGD MGI:3028623