ATP10B - ATPase phospholipid transporting 10B (putative) Gene

Homo sapiens

Also known as ATPVB

Gene ID: 23120 | Gene type: protein coding

About ATP10B

Cytogenetic location: 5q34 Genomic coordinates (GRCh38): 5:160,563,120-160,929,360 (from NCBI)

This gene has 12 transcripts (splice variants), 211 orthologues and 13 paralogues. Biased expression in colon (RPKM 23.9), duodenum (RPKM 11.1) and 7 other tissues.

Summary

Enables glycosylceramide flippase activity and phosphatidylcholine flippase activity. Involved in lysosomal membrane organization. Located in endoplasmic reticulum. Is integral component of lysosomal membrane. Part of phospholipid-translocating ATPase complex. [provided by Alliance of Genome Resources, Apr 2022]

ATP10B Products(9)

mRNA	Protein	Name
NM_001366652.1	NP_001353581.1	phospholipid-transporting ATPase VB isoform 1
NM_001366653.2	NP_001353582.1	phospholipid-transporting ATPase VB isoform 2
NM_001366654.2	NP_001353583.1	phospholipid-transporting ATPase VB isoform 3
NM_001366655.1	NP_001353584.1	phospholipid-transporting ATPase VB isoform 1
NM_001366656.2	NP_001353585.1	phospholipid-transporting ATPase VB isoform 2
NM_001366657.1	NP_001353586.1	phospholipid-transporting ATPase VB isoform 4
NM_001366658.2	NP_001353587.1	phospholipid-transporting ATPase VB isoform 5
NM_001410822.1	NP_001397751.1	phospholipid-transporting ATPase VB isoform 6
NM_025153.3	NP_079429.2	phospholipid-transporting ATPase VB isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables glycosylceramide flippase activity	IDA IDA: Inferred from direct assay	32172343	GOA
enables phosphatidylcholine flippase activity	IDA IDA: Inferred from direct assay	32172343	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21914794	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in lysosomal membrane organization	IDA IDA: Inferred from direct assay	32172343	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	21914794	GOA
located in late endosome membrane	IDA IDA: Inferred from direct assay	26567335	GOA
located in lysosomal membrane	IDA IDA: Inferred from direct assay	25947375	GOA
located in membrane	IDA IDA: Inferred from direct assay	25947375	GOA
part of phospholipid-translocating ATPase complex	IDA IDA: Inferred from direct assay	25947375	GOA
part of phospholipid-translocating ATPase complex	IPI IPI: Inferred from physical interaction	25947375	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATP10B Protein Structure

E1-E2_ATPase

HAD

0
300
600
900
1200
1461 a.a.

Protein Preferred Names

Protein Names

phospholipid-transporting ATPase VB

ATPase, class V, type 10B

Related Diseases

Diseases

Alias

Waardenburg Syndrome, Type 4c

Waardenburg Syndrome Type 4c	WS4C
Waardenburg Syndrome Type Ivc	Waardenburg Syndrome With Hirschsprung Disease Type 4c
Waardenburg Syndrome With Hirschsprung Disease, Type 4c	Waardenburg Syndrome, Type Ivc
Waardenburg Syndrome 4c	Hirschsprung Disease With Pigmentary Anomaly
Shah-Waardenburg Syndrome	Waardenburg-Shah Syndrome
Waardenburg Syndrome, Type 4a

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01172	ATP10B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ATP10B	MGD	MGI:2442688
Rattus norvegicus	ATP10B	RGD	RGD:1565126
Felis catus	ATP10B	VGNC	VGNC:102165
Macaca mulatta	ATP10B	VGNC	VGNC:84281

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