FLI1 - Fli-1 proto-oncogene, ETS transcription factor Gene

Homo sapiens

Also known as EWSR2; FLI-1; SIC-1; BDPLT21

Gene ID: 2313 | Gene type: protein coding

About FLI1

Cytogenetic location: 11q24.3 Genomic coordinates (GRCh38): 11:128,685,351-128,813,267 (from NCBI)

This gene has 10 transcripts (splice variants), 212 orthologues, 28 paralogues and is associated with 102 phenotypes. Broad expression in spleen (RPKM 33.9), lymph node (RPKM 17.6) and 20 other tissues.

Summary

This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

FLI1 Products(4)

mRNA	Protein	Name
NM_001167681.3	NP_001161153.1	Friend leukemia integration 1 transcription factor isoform 2
NM_001271010.2	NP_001257939.1	Friend leukemia integration 1 transcription factor isoform 3
NM_001271012.2	NP_001257941.1	Friend leukemia integration 1 transcription factor isoform 4
NM_002017.5	NP_002008.2	Friend leukemia integration 1 transcription factor isoform 1

FLI1 Protein Structure

SAM_PNT

Ets

0
100
200
300
400
452 a.a.

Protein Preferred Names

Protein Names

Friend leukemia integration 1 transcription factor

Ewing sarcoma breakpoint region 2

FLI1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FLI1	Q01543	SMAD3	Homo sapiens	P84022	Y2H Array	20211142
Intra	FLI1	Q01543	SOX30	Homo sapiens	O94993	Y2H Array	25416956
Intra	FLI1	Q01543	SIAH1	Homo sapiens	Q8IUQ4	Validated Y2H	25416956
Intra	FLI1	Q01543	SIAH1	Homo sapiens	Q8IUQ4	Y2H Array	25416956
Intra	FLI1	Q01543	SIAH1	Homo sapiens	Q8IUQ4	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Bleeding Disorder, Platelet-Type, 21

BDPLT21

Isolated Delta-Storage Pool Disease

Isolated Delta-Spd	Isolated Dense-Spd
Isolated Dense-Storage Pool Disease

Ewing Sarcoma

Neuroepithelioma	Ewing'S Tumor
Primitive Neuroectodermal Tumor	Ewings Sarcoma
Ewing'S Sarcoma	Peripheral Neuroepithelioma
ES	Ewings Sarcoma-Primitive Neuroectodermal Tumor
Localized Peripheral Primitive Neuroectodermal Tumor	Peripheral Primitive Neuroectodermal Tumor
Ewing Tumor	Sarcoma, Ewing'S
Ewing Family Of Tumors	Extraosseous Ewing Tumor
Askin Tumor	Ewing'S Family Localized Tumor
Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor	Localized Ewing Sarcoma
Localized Ewing'S Sarcoma	Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor
Localized Ewing'S Tumor	Pnet Of Thoracopulmonary Region
Tumor Of The Ewing Family	Skeletal Ewing Sarcoma
Osseous Ewing Sarcoma	Ppnet
Peripheral Pnet	Extraskeletal Ewing Sarcoma
Eoe	Extraosseous Ewing Sarcoma
Extraskeletal Ewing Tumor	Esft
Ewing Sarcoma Family Of Tumors	Pne
Pnet	Pnet Of The Chest Wall
Sarcoma, Ewing	Neuroectodermal Tumors, Primitive, Peripheral
Neuroectodermal Tumor, Primitive	Disorder Of Eye
Askin'S Tumor	Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor
Neuroepithelioma, Peripheral

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Jacobsen Syndrome

Chromosome 11q Deletion Syndrome	Partial 11q Monosomy Syndrome
Jacobsen Distal 11q Deletion Syndrome	JBS
11q Partial Monosomy Syndrome	Chromosome 11q Deletion
11q Deletion	11q Monosomy
Deletion 11q	Monosomy 11q
Partial Monosomy 11q	11q Deletion Disorder
11q Deletion Syndrome	11q Terminal Deletion Disorder
11q- Deletion Syndrome	11q23 Deletion Disorder
Jacobsen Thrombocytopenia	11q Terminal Deletion Syndrome
Del(11)(Q23.3)	Del(11)(Qter)
Distal Deletion 11q	Distal Monosomy 11q
Monosomy 11qter	Telomeric Deletion 11q
Paris-Trousseau Thrombocytopenia

Thrombocytopenia, Paris-Trousseau Type

Paris-Trousseau Thrombocytopenia	TCPT
Paris-Trousseau Syndrome	Thrombocytopenia Paris-Trousseau Type
Chromosome 11q23 Deletion Syndrome	Jacobsen Distal 11q Deletion Syndrome

Sarcoma

Connective And Soft Tissue Neoplasm	Tumor Of Soft Tissue And Skeleton
Sarcomas	Sarcoma - Category

Leukemia

Leukemias	Leukaemia, Unspecified, Without Mention Of Remission
Aleukemic Leukaemia	Chronic Leukaemia
Subacute Leukaemia	Leukaemia Disorder
Leukaemia Nos

Hemangioendothelioma

Lymphoblastic Lymphoma

Lymphoma, Lymphoblastic	Lymphoma Lymphoblastic
Precursor Cell Lymphoblastic Lymphoma	Precursor Cell Lymphoblastic Leukemia Lymphoma

Erythroleukemia

Angiosarcoma

Hemangiosarcoma

Vascular Cancer

Blood Vessel Tumors	Malignant Vascular Neoplasm
Renal Vein Leiomyosarcoma	Vascular Neoplasms
Blood Vessel Neoplasm	Blood Vessel Tumor
Blood Vessel Tumour Disorder	Haemangiomatous Tumour
Leiomyosarcoma Of The Renal Vein	Malignant Great Vessel Tumor
Malignant Tumor Of Pulmonary Artery	Malignant Tumor Of Pulmonary Vein
Malignant Vascular Tumor	Neoplasm Of Great Vessel
Pulmonary Artery Malignant Neoplasm	Pulmonary Vein Malignant Neoplasm
Vascular Tissue Neoplasm	Vascular Tumors
Blood Vessel Cancer	Neoplasms, Vascular Tissue
Malignant Neoplasm Of Great Vessels

Ewing Sarcoma Of Bone

Ewing'S Sarcoma Of Bone	Bone Ewing Sarcoma
Bone Ewing'S Sarcoma	Bone Localized Ewing Sarcoma
Bone Localized Ewing'S Sarcoma	Ewing'S Sarcoma/Bone Peripheral Primitive Neuroectodermal Tumor
Localized Skeletal Ewing'S Sarcoma	Localized Bone Ewing Sarcoma

Epithelioid Sarcoma

Epithelioid Cell Sarcoma	Sarcoma Epithelioid
Sarcoma, Epithelioid

Intracranial Primitive Neuroectodermal Tumor

Intracranial Pnet

Intracranial Primitive Neuroectodermal Neoplasm

Sarcoma, Synovial

Synovial Sarcoma	Synovialosarcoma
Synovial Cell Sarcoma	Sarcoma Synovial

Hemangioma

Hemangiomas

Askin'S Tumor

Askin Tumor	Askin Tumour
Askin'S Tumour

Malignant Epithelioid Hemangioendothelioma

Epithelioid Hemangioendothelioma, Malignant

Malignant Hemangioma

Small Cell Osteogenic Sarcoma

Small Cell Osteosarcoma	Round Cell Osteosarcoma
Osteosarcoma Small Cell

Olfactory Neuroblastoma

Esthesioneuroblastoma	Asthesioneuroblastoma
Esthesioneuroepithelioma	Olfactory Esthesioneuroblastoma
Paranasal Sinus Olfactory Neuroblastoma	Esthesioneuroblastoma, Olfactory
Esthesioneuroblastoma Of Nasal Cavity

Hobnail Hemangioma

Acute Erythroid Leukemia

Acute Erythroleukemia	Di Guglielmo'S Syndrome
Aml M6	Acute Myeloid Leukemia Fab-M6
Acute Myeloid Leukemia M6	Erythroleukemia
Aml-M6	Acute Erythroleukemia M6a Subtype
Acute Erythroleukemia M6b Subtype	Di Guglielmo Syndrome
Acute Myeloid Leukemia, M6 Type	Acute Erythroblastic Leukemia
Acute Erythroleukemia - M6a Subtype	Acute Erythroleukemia - M6b Subtype
Acute Erythraemia And Erythroleukaemia	Acute Erythroid Leukaemia Without Mention Of Remission
Erythraemia	Erythraemic Myelosis
Erythroleukaemia	Acute Erythraemic Myelosis
Acute Erythraemia

Intravascular Fasciitis

Intravascular Pseudosarcomatous Fasciitis

Rhabdomyosarcoma

Bone Osteosarcoma

Osteosarcoma Of Bone

Primary Osteosarcoma Of Bone

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-122903	TK216	Inhibitor	99.84%	Phase 2

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14507	YK-4-279		99.91%	Unkown
HY-163325	Fli-1-IN-1 fumarate	Inhibitor	/	Unkown
HY-163325A	Fli-1-IN-1	Inhibitor	/	Unkown
HY-RS04977	FLI1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	FLI1	VGNC	VGNC:72669
Felis catus	FLI1	VGNC	VGNC:102888
Mus musculus	FLI1	MGD	MGI:95554
Rattus norvegicus	FLI1	RGD	RGD:1309837
Canis familiaris	FLI1	VGNC	VGNC:40898
Bos taurus	FLI1	VGNC	VGNC:29031
Others	FLI1	NCBI

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