2. Gene
  3. FRMD4B - FERM domain containing 4B Gene

FRMD4B - FERM domain containing 4B Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as GRSP1; 6030440G05Rik

Gene ID: 23150 | Gene type: protein coding

About FRMD4B

Cytogenetic location: 3p14.1 Genomic coordinates (GRCh38): 3:69,168,782-69,542,586 (from NCBI)

This gene has 18 transcripts (splice variants), 265 orthologues and 6 paralogues. Ubiquitous expression in spleen (RPKM 7.8), esophagus (RPKM 7.0) and 25 other tissues.

Summary

This gene encodes a GRP1-binding protein which contains a FERM protein interaction domain as well as two coiled coil domains. This protein may play a role as a scaffolding protein. [provided by RefSeq, Mar 2014]

FRMD4B Products(1)

mRNA Protein Name
NM_015123.3 NP_055938.2 FERM domain-containing protein 4B

FRMD4B Protein Structure

FERM_N

FERM_N: FERM N-terminal domain (63 - 142)

FERM_M

FERM_M: FERM central domain (148 - 260)

FERM_C

FERM_C: FERM C-terminal PH-like domain (264 - 364)

DUF3338

DUF3338: Domain of unknown function (DUF3338) (395 - 530)

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  • 1034 a.a.
Protein Preferred Names Protein Names

FERM domain-containing protein 4B

GRP1-binding protein GRSP1

Related Diseases

Diseases Alias
Retinitis Pigmentosa 19

RP19

Retinitis Pigmentosa-19

Retinitis Pigmentosa, Type 19
Urocanase Deficiency

Encephalopathy Due To Urocanase Deficiency

Urocanate Hydratase Deficiency

Urocanic Aciduria

UROCD

High Urine Urocanic Acid Levels
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05102 FRMD4B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta FRMD4B VGNC VGNC:72780
Canis familiaris FRMD4B VGNC VGNC:40981
Mus musculus FRMD4B MGD MGI:2141794
Rattus norvegicus FRMD4B RGD RGD:620172
Bos taurus FRMD4B VGNC VGNC:29115
Felis catus FRMD4B VGNC VGNC:62361