P2rx2 - purinergic receptor P2X, ligand-gated ion channel, 2 Gene

Mus musculus

Also known as P2x2; P2X2a

Gene ID: 231602 | Gene type: protein coding

About P2rx2

Chromosome 5: 110,487,678-110,491,078 reverse strand.GRCm39:CM000998.3

This gene has 6 transcripts (splice variants), 190 orthologues, 6 paralogues and is associated with 8 phenotypes. Biased expression in testis adult (RPKM 29.2), genital fat pad adult (RPKM 19.6) and 5 other tissues.

Summary

Enables extracellularly ATP-gated cation channel activity. Involved in sensory perception of sound. Acts upstream of or within several processes, including response to ATP; skeletal muscle fiber development; and smooth muscle contraction. Located in plasma membrane. Is expressed in facial ganglion; heart; medulla oblongata basal plate mantle layer; and vagus ganglion. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 41. Orthologous to human P2RX2 (purinergic receptor P2X 2). [provided by Alliance of Genome Resources, Apr 2022]

P2rx2 Products(5)

mRNA	Protein	Name
NM_001164834.1	NP_001158306.1	P2X purinoceptor 2 isoform c
NM_001310700.1	NP_001297629.1	P2X purinoceptor 2 isoform d
NM_001164833.1	NP_001158305.1	P2X purinoceptor 2 isoform b
NM_153400.4	NP_700449.2	P2X purinoceptor 2 isoform a
NM_001310701.1	NP_001297630.1	P2X purinoceptor 2 isoform e

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables extracellularly ATP-gated monoatomic cation channel activity	IDA IDA: Inferred from direct assay	12917379	MGI
enables extracellularly ATP-gated monoatomic cation channel activity	IGI IGI: Inferred from genetic interaction	15081800	MGI
enables extracellularly ATP-gated monoatomic cation channel activity	IMP IMP: Inferred from mutant phenotype	15081800	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within behavioral response to pain	IGI IGI: Inferred from genetic interaction	15961431	MGI
acts upstream of or within behavioral response to pain	IMP IMP: Inferred from mutant phenotype	15961431	MGI
acts upstream of or within chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	12917379	MGI
acts upstream of or within detection of hypoxic conditions in blood by carotid body chemoreceptor signaling	IMP IMP: Inferred from mutant phenotype	14672995	MGI
acts upstream of or within neuromuscular junction development	IMP IMP: Inferred from mutant phenotype	17706883	MGI
acts upstream of or within neuromuscular synaptic transmission	IMP IMP: Inferred from mutant phenotype	12937291	MGI
acts upstream of or within peristalsis	IMP IMP: Inferred from mutant phenotype	12937291	MGI
acts upstream of or within response to ATP	IGI IGI: Inferred from genetic interaction	15961431	MGI
acts upstream of or within response to ATP	IMP IMP: Inferred from mutant phenotype	15572362	MGI
acts upstream of or within response to carbohydrate	IMP IMP: Inferred from mutant phenotype	16322458	MGI
acts upstream of or within response to hypoxia	IMP IMP: Inferred from mutant phenotype	14672995	MGI
involved in sensory perception of sound	IMP IMP: Inferred from mutant phenotype	23345450	MGI
acts upstream of or within sensory perception of taste	IGI IGI: Inferred from genetic interaction	16322458	MGI
acts upstream of or within skeletal muscle fiber development	IMP IMP: Inferred from mutant phenotype	17706883	MGI
acts upstream of or within urinary bladder smooth muscle contraction	IGI IGI: Inferred from genetic interaction	15961431	MGI
acts upstream of or within urinary bladder smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	15961431	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in intracellular anatomical structure	IDA IDA: Inferred from direct assay	15961431	MGI
is active in neuronal dense core vesicle	EXP EXP: Inferred from Experiment	21321602	MGI
is active in neuronal dense core vesicle	IDA IDA: Inferred from direct assay	21321602	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	17706883	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

P2rx2 Protein Structure

P2X

0
100
200
300
400
485 a.a.

Protein Preferred Names

Protein Names

P2X purinoceptor 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09900	P2RX2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09901	P2rx2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09902	P2rx2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	P2rx2	NCBI	NCBI:22953

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