ZC3H4 - zinc finger CCCH-type containing 4 Gene

Homo sapiens

Also known as C19orf7

Gene ID: 23211 | Gene type: protein coding

About ZC3H4

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:47,064,187-47,113,776 (from NCBI)

This gene has 5 transcripts (splice variants), 199 orthologues and 2 paralogues. Ubiquitous expression in spleen (RPKM 3.8), ovary (RPKM 2.9) and 25 other tissues.

Summary

This gene encodes a member of a family of CCCH (C-x8-C-x5-C-x3-H type) zinc finger domain-containing proteins. These zinc finger domains, which coordinate zinc finger binding and are characterized by three cysteine residues and one histidine residue, are nucleic acid-binding. Other family members are known to function in post-transcriptional regulation. [provided by RefSeq, Aug 2011]

ZC3H4 Products(1)

mRNA	Protein	Name
NM_015168.2	NP_055983.1	zinc finger CCCH domain-containing protein 4

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA binding	IDA IDA: Inferred from direct assay	33913806	GOA
enables promoter-specific chromatin binding	IDA IDA: Inferred from direct assay	33913806	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	33913806	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in lncRNA catabolic process	IDA IDA: Inferred from direct assay	33913806	GOA
involved in negative regulation of DNA-templated transcription, elongation	IDA IDA: Inferred from direct assay	33913806	GOA
involved in negative regulation of lncRNA transcription	IDA IDA: Inferred from direct assay	33913806	GOA
involved in nuclear RNA surveillance	IDA IDA: Inferred from direct assay	33913806	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZC3H4 Protein Structure

zf-CCCH

0
200
400
600
800
1000
1200
1303 a.a.

Protein Preferred Names

Protein Names

zinc finger CCCH domain-containing protein 4

Related Diseases

Diseases

Alias

Pulmonary Talcosis

Pneumoconiosis Due To Talc	Talc Pneumoconiosis
Talcosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15993	ZC3H4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ZC3H4	VGNC	VGNC:48559
Felis catus	ZC3H4	VGNC	VGNC:67186
Mus musculus	ZC3H4	MGD	MGI:2682314
Rattus norvegicus	ZC3H4	RGD	RGD:1596943
Bos taurus	ZC3H4	VGNC	VGNC:37106
Macaca mulatta	ZC3H4	VGNC	VGNC:79094

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