1. Gene
  2. FMO2 - flavin containing dimethylaniline monoxygenase 2 Gene

FMO2 - flavin containing dimethylaniline monoxygenase 2 Gene

Homo sapiens

Also known as FMO1B1

Gene ID: 2327 | Gene type: protein coding

About FMO2

Cytogenetic location: 1q24.3 Genomic coordinates (GRCh38): 1:171,185,208-171,212,686 (from NCBI)

This gene has 7 transcripts (splice variants), 136 orthologues and 5 paralogues. Biased expression in fat (RPKM 59.7), lung (RPKM 58.7) and 8 other tissues.

Summary

This gene encodes a flavin-containing monooxygenase family member. It is an NADPH-dependent Enzyme that catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate. However, some human populations contain an allele (FMO2*2A) with a premature stop codon, resulting in a protein that is C-terminally-truncated, has no catalytic activity, and is likely degraded rapidly. This gene is found in a cluster with Other related family members on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]

FMO2 Products(3)

mRNA Protein Name
NM_001301347.2 NP_001288276.1 flavin-containing monooxygenase 2 isoform b
NM_001365900.1 NP_001352829.1 flavin-containing monooxygenase 2 isoform c
NM_001460.5 NP_001451.2 flavin-containing monooxygenase 2 isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables N,N-dimethylaniline monooxygenase activity IDA
IDA: Inferred from direct assay
11744609 GOA
Biological Process GO Annotation Evidence Reference Source
involved in NADP metabolic process IDA
IDA: Inferred from direct assay
11744609 GOA
involved in NADPH oxidation IDA
IDA: Inferred from direct assay
9804831 GOA
involved in organic acid metabolic process IDA
IDA: Inferred from direct assay
11744609 GOA
involved in toxin metabolic process IDA
IDA: Inferred from direct assay
11744609 GOA
involved in xenobiotic metabolic process IDA
IDA: Inferred from direct assay
11744609 GOA
Cellular Component GO Annotation Evidence Reference Source
located in membrane IDA
IDA: Inferred from direct assay
9804831 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FMO2 Protein Structure

FMO-like

FMO-like: Flavin-binding monooxygenase-like (2 - 471)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 471 a.a.
Protein Preferred Names Protein Names

flavin-containing monooxygenase 2

FMO, pulmonary

Related Diseases

Diseases Alias
Trimethylaminuria

TMAU

Fish-Odor Syndrome

Fish Malodor Syndrome

Fish Odor Syndrome

Stale Fish Syndrome

Tmauria

Severe Primary Trimethylaminuria

Mesh

D008661

Fish Odour Syndrome

Prader-Willi Syndrome

Prader-Labhart-Willi Syndrome

PWS

Willi-Prader Syndrome

Prader-Willi Syndrome Due To Translocation

Prader-Willi Syndrome Due To Imprinting Mutation

Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15

Prader Willi Syndrome

Upd(15)Mat

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Macaca mulatta FMO2 VGNC VGNC:72683
Felis catus FMO2 VGNC VGNC:62308
Bos taurus FMO2 VGNC VGNC:29050
Canis familiaris FMO2 VGNC VGNC:40917
Rattus norvegicus FMO2 RGD RGD:628600
Mus musculus FMO2 MGD MGI:1916776