FMO2 - flavin containing dimethylaniline monoxygenase 2 Gene

Homo sapiens

Also known as FMO1B1

Gene ID: 2327 | Gene type: protein coding

About FMO2

Cytogenetic location: 1q24.3 Genomic coordinates (GRCh38): 1:171,185,208-171,212,686 (from NCBI)

This gene has 7 transcripts (splice variants), 136 orthologues and 5 paralogues. Biased expression in fat (RPKM 59.7), lung (RPKM 58.7) and 8 other tissues.

Summary

This gene encodes a flavin-containing monooxygenase family member. It is an NADPH-dependent Enzyme that catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate. However, some human populations contain an allele (FMO2*2A) with a premature stop codon, resulting in a protein that is C-terminally-truncated, has no catalytic activity, and is likely degraded rapidly. This gene is found in a cluster with Other related family members on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]

FMO2 Products(3)

mRNA	Protein	Name
NM_001301347.2	NP_001288276.1	flavin-containing monooxygenase 2 isoform b
NM_001365900.1	NP_001352829.1	flavin-containing monooxygenase 2 isoform c
NM_001460.5	NP_001451.2	flavin-containing monooxygenase 2 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables N,N-dimethylaniline monooxygenase activity	IDA IDA: Inferred from direct assay	11744609	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in NADP metabolic process	IDA IDA: Inferred from direct assay	11744609	GOA
involved in NADPH oxidation	IDA IDA: Inferred from direct assay	9804831	GOA
involved in organic acid metabolic process	IDA IDA: Inferred from direct assay	11744609	GOA
involved in toxin metabolic process	IDA IDA: Inferred from direct assay	11744609	GOA
involved in xenobiotic metabolic process	IDA IDA: Inferred from direct assay	11744609	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane	IDA IDA: Inferred from direct assay	9804831	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FMO2 Protein Structure

FMO-like

0
100
200
300
400
471 a.a.

Protein Preferred Names

Protein Names

flavin-containing monooxygenase 2

FMO, pulmonary

Related Diseases

Diseases

Alias

Trimethylaminuria

TMAU	Fish-Odor Syndrome
Fish Malodor Syndrome	Fish Odor Syndrome
Stale Fish Syndrome	Tmauria
Severe Primary Trimethylaminuria	Mesh
D008661	Fish Odour Syndrome

Prader-Willi Syndrome

Prader-Labhart-Willi Syndrome	PWS
Willi-Prader Syndrome	Prader-Willi Syndrome Due To Translocation
Prader-Willi Syndrome Due To Imprinting Mutation	Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15
Prader Willi Syndrome	Upd(15)Mat

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05006	FMO2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	FMO2	VGNC	VGNC:72683
Felis catus	FMO2	VGNC	VGNC:62308
Bos taurus	FMO2	VGNC	VGNC:29050
Canis familiaris	FMO2	VGNC	VGNC:40917
Rattus norvegicus	FMO2	RGD	RGD:628600
Mus musculus	FMO2	MGD	MGI:1916776

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