WWC1 - WW and C2 domain containing 1 Gene

Homo sapiens

Also known as KIBRA; HBEBP3; HBEBP36; MEMRYQTL; PPP1R168

Gene ID: 23286 | Gene type: protein coding

About WWC1

Cytogenetic location: 5q34 Genomic coordinates (GRCh38): 5:168,291,645-168,472,303 (from NCBI)

This gene has 16 transcripts (splice variants), 218 orthologues, 2 paralogues and is associated with 1 phenotype. Broad expression in salivary gland (RPKM 17.1), kidney (RPKM 16.5) and 17 other tissues.

Summary

The protein encoded by this gene is a cytoplasmic phosphoprotein that interacts with PRKC-zeta and dynein light chain-1. Alleles of this gene have been found that enhance memory in some individuals. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

WWC1 Products(3)

mRNA	Protein	Name
NM_001161661.2	NP_001155133.1	protein KIBRA isoform 1
NM_001161662.2	NP_001155134.1	protein KIBRA isoform 2
NM_015238.3	NP_056053.1	protein KIBRA isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables kinase binding	IPI IPI: Inferred from physical interaction	24682284	GOA
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	24682284	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16684779	GOA
enables signaling adaptor activity	IDA IDA: Inferred from direct assay	35429439	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	16684779	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell migration	IDA IDA: Inferred from direct assay	18596123	GOA
involved in hippo signaling	IDA IDA: Inferred from direct assay	35429439	GOA
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	24682284	GOA
involved in negative regulation of hippo signaling	IDA IDA: Inferred from direct assay	24682284	GOA
involved in negative regulation of organ growth	IMP IMP: Inferred from mutant phenotype	24682284	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	24682284	GOA
involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	18190796	GOA
involved in regulation of hippo signaling	IMP IMP: Inferred from mutant phenotype	20159598	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	35429439	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	16684779	GOA
located in cytosol	IDA IDA: Inferred from direct assay	24682284	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16684779	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	18596123	GOA
located in ruffle membrane	IDA IDA: Inferred from direct assay	18190796	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WWC1 Protein Structure

0
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600
800
1000
1113 a.a.

Protein Preferred Names

Protein Names

protein KIBRA

HBeAg-binding protein 3

Related Diseases

Diseases

Alias

Memory Quantitative Trait Locus

MEMRYQTL

Memory, Enhanced, Qtl

Neurofibromatosis, Type Ii

Neurofibromatosis 2	Neurofibromatosis, Type 2
NF2	Neurofibromatosis Type Ii
Bilateral Acoustic Neurofibromatosis	Banf
Acn	Central Neurofibromatosis
Neurofibromatosis, Central Type	Acoustic Schwannomas, Bilateral
Acoustic Neurinoma, Bilateral	Bilateral Acoustic Neurinoma
Bilateral Acoustic Schwannomas	Familial Acoustic Neuromas

Bjornstad Syndrome

BJS	Pili Torti And Nerve Deafness
Ptd	Pili Torti-Deafness Syndrome
Deafness-Pili Torti-Hypogonadism Syndrome	Deafness And Pili Torti, Bjornstad Type
Pili Torti-Sensorineural Hearing Loss	Björnstad Syndrome
Ptnd	Hearing Loss-Pili Torti-Hypogonadism Syndrome
Bjoernstad Syndrome

Sveinsson Chorioretinal Atrophy

SCRA	Atrophia Areata
Helicoid Peripapillary Chorioretinal Degeneration	Hpcd
Aa	Peripapillary Chorioretinal Degeneration, Icelandic Type
Helicoidal Peripapillary Chorioretinal Degeneration	Atrophy, Chorioretinal, Sveinsson

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15856	WWC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	WWC1	VGNC	VGNC:48439
Felis catus	WWC1	VGNC	VGNC:67096
Bos taurus	WWC1	VGNC	VGNC:36974
Macaca mulatta	WWC1	VGNC	VGNC:79809
Rattus norvegicus	WWC1	RGD	RGD:1308329
Mus musculus	WWC1	MGD	MGI:2388637

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