2. Gene
  3. FMO5 - flavin containing dimethylaniline monoxygenase 5 Gene

FMO5 - flavin containing dimethylaniline monoxygenase 5 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as hBVMO1

Gene ID: 2330 | Gene type: protein coding

About FMO5

Cytogenetic location: 1q21.1 Genomic coordinates (GRCh38): 1:147,184,305-147,227,284 (from NCBI)

This gene has 9 transcripts (splice variants), 162 orthologues and 5 paralogues. Biased expression in liver (RPKM 65.3), small intestine (RPKM 17.2) and 8 other tissues.

Summary

Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the Enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]

FMO5 Products(3)

mRNA Protein Name
NM_001144829.3 NP_001138301.1 flavin-containing monooxygenase 5 isoform 2
NM_001144830.3 NP_001138302.1 flavin-containing monooxygenase 5 isoform 3
NM_001461.4 NP_001452.2 flavin-containing monooxygenase 5 isoform 1

FMO5 Protein Structure

FMO-like

FMO-like: Flavin-binding monooxygenase-like (3 - 532)

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  • 533 a.a.
Protein Preferred Names Protein Names

flavin-containing monooxygenase 5

FMO 5

Related Diseases

Diseases Alias
Trimethylaminuria

TMAU

Fish-Odor Syndrome

Fish Malodor Syndrome

Fish Odor Syndrome

Stale Fish Syndrome

Tmauria

Severe Primary Trimethylaminuria

Mesh

D008661

Fish Odour Syndrome
Chromosome 1q21.1 Deletion Syndrome, 1.35-Mb

Chromosome 1q21.1 Deletion Syndrome

1q21.1 Microdeletion Syndrome

Monosomy 1q21.1

1q21.1 Microdeletion

Chromosome 1q21.1 Microdeletion Syndrome

1q21.1 Contiguous Gene Deletion

1q21.1 Deletion

Del(1)(Q21)

1q21.1 Deletion Syndrome
Duodenal Atresia

Duodenal Stenosis

Familial Duodenal Atresia
Chromosome 1p36 Deletion Syndrome

1p36 Deletion Syndrome

Deletion 1p36

Monosomy 1p36

Subtelomeric 1p36 Deletion

Monosomy 1p36 Syndrome

Distal Monosomy 1p36

Del(1)(P36)

Deletion 1pter

Monosomy 1pter
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05009 FMO5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus FMO5 VGNC VGNC:29053
Rattus norvegicus FMO5 RGD RGD:628602
Felis catus FMO5 VGNC VGNC:62311
Macaca mulatta FMO5 VGNC VGNC:72685
Mus musculus FMO5 MGD MGI:1310004
Canis familiaris FMO5 VGNC VGNC:40920