WDR7 - WD repeat domain 7 Gene

Homo sapiens

Also known as TRAG

Gene ID: 23335 | Gene type: protein coding

About WDR7

Cytogenetic location: 18q21.31 Genomic coordinates (GRCh38): 18:56,651,359-57,036,606 (from NCBI)

This gene has 12 transcripts (splice variants), 212 orthologues and 26 paralogues. Ubiquitous expression in brain (RPKM 12.4), thyroid (RPKM 5.9) and 24 other tissues.

Summary

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 Amino acids typically bracketed by gly-his and trp-asp (GH-WD) that may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, Apoptosis, and gene regulation. The encoded protein forms the beta subunit of rabconnectin-3 and binds directly with Rab3A GDP/GTP exchange protein and indirectly with Rab3A GDP/GTP activating protein; these proteins are regulators of Rab3 small G protein family members involved in control of the calcium-dependant exocytosis of neurotransmitters. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

WDR7 Products(4)

mRNA	Protein	Name
NM_001382485.1	NP_001369414.1	WD repeat-containing protein 7 isoform 2
NM_001382487.1	NP_001369416.1	WD repeat-containing protein 7 isoform 1
NM_015285.3	NP_056100.2	WD repeat-containing protein 7 isoform 1
NM_052834.3	NP_443066.2	WD repeat-containing protein 7 isoform 2

WDR7 Protein Structure

WD40

0
300
600
900
1200
1490 a.a.

Protein Preferred Names

Protein Names

WD repeat-containing protein 7

TGF-beta resistance associated

Related Diseases

Diseases

Alias

Retinitis Pigmentosa 4

RP4	Retinitis Pigmentosa 4, Autosomal Dominant Or Recessive
Retinitis Pigmentosa, Rhodopsin-Related	Retinitis Pigmentosa, Type 4

Aleutian Mink Disease

Aleutian Disease

Kohlschutter-Tonz Syndrome

Amelocerebrohypohidrotic Syndrome	KTZS
Epilepsy And Yellow Teeth	Kohlschutter Tonz Syndrome
Kohlschutter Syndrome	Epilepsy Dementia Amelogenesis Imperfecta
Epilepsy-Dementia-Amelogenesis Imperfecta Syndrome	Epilepsy, Dementia, And Amelogenesis Imperfecta
Kohlschutter'S Syndrome	Kohlschütter-Tönz Syndrome
Kohlschuetter-Toenz Syndrome	Presenile Dementia
Dementia

Ulcerative Stomatitis

Stomatitis Ulcerative	Aphthous Stomatitis
Minor Oral Aphthous Ulceration

Optic Atrophy 3, Autosomal Dominant

Optic Atrophy 3	OPA3
Autosomal Dominant Optic Atrophy And Cataract	Optic Atrophy And Cataract, Autosomal Dominant
Autosomal Dominant Optic Atrophy Type 3	Optic Atrophy 3 With Cataract
Opa3, Autosomal Dominant	Adoac
Optic Atrophy, Cataract, And Neurologic Disorder	Autosomal Dominant Optic Atrophy 3
Optic Atrophy Type 3	Optic Atrophy 3 Autosomal Dominant
Atrophy, Optic, Type 3, Autosomal Dominant	3-Methylglutaconic Aciduria Type 3

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15792	WDR7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	WDR7	VGNC	VGNC:67049
Macaca mulatta	WDR7	VGNC	VGNC:78929
Rattus norvegicus	WDR7	RGD	RGD:619836
Bos taurus	WDR7	VGNC	VGNC:36914
Canis familiaris	WDR7	VGNC	VGNC:48383
Mus musculus	WDR7	MGD	MGI:1860197
Others	WDR7	NCBI

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