ANGEL1 - angel homolog 1 Gene

Homo sapiens

Also known as Ccr4e; KIAA0759

Gene ID: 23357 | Gene type: protein coding

About ANGEL1

Cytogenetic location: 14q24.3 Genomic coordinates (GRCh38): 14:76,786,009-76,812,882 (from NCBI)

This gene has 6 transcripts (splice variants), 209 orthologues and 5 paralogues. Broad expression in testis (RPKM 25.2), spleen (RPKM 10.7) and 25 other tissues.

Summary

Enables eukaryotic initiation factor 4E binding activity and protein domain specific binding activity. Predicted to be involved in RNA phosphodiester bond hydrolysis, exonucleolytic. Located in several cellular components, including cis-Golgi network; endoplasmic reticulum; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ANGEL1 Products(4)

mRNA	Protein	Name
NM_001370746.1	NP_001357675.1	protein angel homolog 1 isoform 1 precursor
NM_001370747.1	NP_001357676.1	protein angel homolog 1 isoform 2 precursor
NM_001370748.1	NP_001357677.1	protein angel homolog 1 isoform 3 precursor
NM_015305.4	NP_056120.2	protein angel homolog 1 isoform 4 precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables eukaryotic initiation factor 4E binding	IDA IDA: Inferred from direct assay	23814182	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	31413325	GOA
enables protein domain specific binding	IDA IDA: Inferred from direct assay	23814182	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cis-Golgi network	IDA IDA: Inferred from direct assay	23814182	GOA
located in cytosol	IDA IDA: Inferred from direct assay	23814182	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	23814182	GOA
is active in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	36180430	GOA
located in nucleus	IDA IDA: Inferred from direct assay	23814182	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	23814182	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ANGEL1 Protein Structure

Exo_endo_phos

0
200
400
600
670 a.a.

Protein Preferred Names

Protein Names

protein angel homolog 1

Related Diseases

Diseases

Alias

Arrhythmogenic Right Ventricular Dysplasia, Familial, 9

Arrhythmogenic Right Ventricular Dysplasia 9	ARVD9
Arrhythmogenic Right Ventricular Cardiomyopathy 9	Arvc9
Familial Arrhythmogenic Right Ventricular Dysplasia 9	Dysplasia, Arrhythmogenic Right Ventricular, Type 9

Cranioectodermal Dysplasia 1

Sensenbrenner Syndrome	CED1
Levin Syndrome I	Cranio-Ectodermal Dysplasia
Dysplasia, Cranioectodermal, Type 1	Cranioectodermal Dysplasia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00685	ANGEL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ANGEL1	VGNC	VGNC:59778
Bos taurus	ANGEL1	VGNC	VGNC:25886
Macaca mulatta	ANGEL1	VGNC	VGNC:69639
Rattus norvegicus	ANGEL1	RGD	RGD:1306238
Canis familiaris	ANGEL1	VGNC	VGNC:37852
Mus musculus	ANGEL1	MGD	MGI:1915987

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