USP24 - ubiquitin specific peptidase 24 Gene

Homo sapiens

Gene ID: 23358 | Gene type: protein coding

About USP24

Cytogenetic location: 1p32.3 Genomic coordinates (GRCh38): 1:55,066,359-55,215,364 (from NCBI)

This gene has 7 transcripts (splice variants), 164 orthologues and 71 paralogues. Ubiquitous expression in bone marrow (RPKM 9.9), lymph node (RPKM 9.7) and 25 other tissues.

Summary

Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating Enzymes. USP24 belongs to a large family of cysteine proteases that function as deubiquitinating Enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Mar 2008]

USP24 Products(1)

mRNA	Protein	Name
NM_015306.3	NP_056121.2	ubiquitin carboxyl-terminal hydrolase 24

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USP24 Protein Structure

UCH

0
500
1000
1500
2000
2620 a.a.

Protein Preferred Names

Protein Names

ubiquitin carboxyl-terminal hydrolase 24

deubiquitinating enzyme 24

Related Diseases

Diseases

Alias

Non-Syndromic X-Linked Intellectual Disability 99

Mrx99

X-Linked Mental Retardation 99

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-111408	EOAI3402143	Inhibitor	98.95%	Unkown
HY-RS15534	USP24 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	USP24	VGNC	VGNC:78743
Rattus norvegicus	USP24	RGD	RGD:1306799
Felis catus	USP24	VGNC	VGNC:66874
Mus musculus	USP24	MGD	MGI:1919936
Bos taurus	USP24	VGNC	VGNC:36717
Canis familiaris	USP24	VGNC	VGNC:48183

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