2. Gene
  3. PPWD1 - peptidylprolyl isomerase domain and WD repeat containing 1 Gene

PPWD1 - peptidylprolyl isomerase domain and WD repeat containing 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 23398 | Gene type: protein coding

About PPWD1

Cytogenetic location: 5q12.3 Genomic coordinates (GRCh38): 5:65,563,296-65,587,549 (from NCBI)

This gene has 15 transcripts (splice variants), 196 orthologues and 22 paralogues. Ubiquitous expression in lymph node (RPKM 13.9), appendix (RPKM 11.8) and 25 other tissues.

Summary

Enables cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Involved in protein peptidyl-prolyl isomerization. Located in nuclear body. Part of catalytic step 2 spliceosome. [provided by Alliance of Genome Resources, Apr 2022]

PPWD1 Products(4)

mRNA Protein Name
NM_001278926.2 NP_001265855.1 peptidylprolyl isomerase domain and WD repeat-containing protein 1 isoform 2
NM_001278927.2 NP_001265856.1 peptidylprolyl isomerase domain and WD repeat-containing protein 1 isoform 3
NM_001278929.2 NP_001265858.1 peptidylprolyl isomerase domain and WD repeat-containing protein 1 isoform 4
NM_015342.4 NP_056157.1 peptidylprolyl isomerase domain and WD repeat-containing protein 1 isoform 1
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables peptidyl-prolyl cis-trans isomerase activity IDA
IDA: Inferred from direct assay
20676357 GOA
Cellular Component GO Annotation Evidence Reference Source
part of catalytic step 2 spliceosome IDA
IDA: Inferred from direct assay
11991638 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPWD1 Protein Structure

WD40

WD40: WD domain, G-beta repeat (88 - 117)

WD40

WD40: WD domain, G-beta repeat (125 - 161)

WD40

WD40: WD domain, G-beta repeat (284 - 307)

Pro_isomerase

Pro_isomerase: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD (495 - 644)

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  • 646 a.a.
Protein Preferred Names Protein Names

peptidylprolyl isomerase domain and WD repeat-containing protein 1

epididymis secretory sperm binding protein

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11041 PPWD1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PPWD1 RGD RGD:1310204
Bos taurus PPWD1 VGNC VGNC:33279
Mus musculus PPWD1 MGD MGI:2443069
Canis familiaris PPWD1 VGNC VGNC:44932
Felis catus PPWD1 VGNC VGNC:64337
Macaca mulatta PPWD1 VGNC VGNC:76339